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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	AF-DX 384
Molecular formula	C27H38N6O2
IUPAC name	N-[2-[2-[(dipropylamino)methyl]piperidin-1-yl]ethyl]-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
Molecular weight	478.641
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	2.8
Synonyms	GTPL368 N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide SR-01000597571-1 (-)-5,11-Dihydro-11-[[[2-[2-[(dipropylamino)methyl]-piperidin-l-yl]ethyl]amino]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one AC1L3ONW BRD-A93436351-001-01-4 L003043 PDSP1_000962 [3H]AF-DX 384 AFDX-384 D0HP1O MZDYABXXPZNUCT-UHFFFAOYSA-N SCHEMBL9824222 5,11-dihydro-11-[[[2-[2-[(dipropylamino)methyl]-piperidin-l-yl]ethyl]amino]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one BDBM81901 HMS3267P13 N-[2-[2-[(dipropylamino)methyl]piperidin-1-yl]ethyl]-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide Z3314 118290-26-9 CAS_119356 CHEMBL279453 LS-187269 PDSP1_000963 AFDX384 GTPL3264 N-(2-(2-((Dipropylamino)methyl)piperidin-1-yl)ethyl)-6-oxo-5H-benzo[e]pyrido[3,2-b][1,4]diazepine-11(6H)-carboxamide SR-01000597571 (+)-5,11-Dihydro-11-[[[2-[2-[(dipropylamino)methyl]-piperidin-l-yl]ethyl]amino]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one BN0056 J-003728 NSC_119356 [3H]AF DX-384 118290-27-0 AF-DX-384 CHEBI:110176 D06PVQ MolPort-003-983-506 PDSP2_000947 5,11-Dihydro-11-[[[2-[2-[(dipropylamino)methyl]-piperidin-1-yl]ethyl]amino]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one AKOS024456538 [ Show all ]
Inchi Key	MZDYABXXPZNUCT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H38N6O2/c1-3-16-31(17-4-2)20-21-10-7-8-18-32(21)19-15-29-27(35)33-24-13-6-5-11-22(24)26(34)30-23-12-9-14-28-25(23)33/h5-6,9,11-14,21H,3-4,7-8,10,15-20H2,1-2H3,(H,29,35)(H,30,34)
PubChem CID	119357
ChEMBL	CHEMBL279453
IUPHAR	3264, 368
BindingDB	81901
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
217762	Muscarinic acetylcholine receptor DM1	P16395	mAChR-A	Drosophila melanogaster (Fruit fly)	805
217763	Muscarinic acetylcholine receptor M1	P11229	CHRM1	Homo sapiens (Human)	460
217761	Muscarinic acetylcholine receptor M2	P08172	CHRM2	Homo sapiens (Human)	466
217759	Muscarinic acetylcholine receptor M3	P20309	CHRM3	Homo sapiens (Human)	590
217760	Muscarinic acetylcholine receptor M4	P08173	CHRM4	Homo sapiens (Human)	479
217764	Muscarinic acetylcholine receptor M5	P08912	CHRM5	Homo sapiens (Human)	532

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