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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H4 receptor
Species	Homo sapiens (Human)
Gene	HRH4
Synonym	Pfi-013 SP9144 HH4R H4R H4 receptor GPRv53 GPCR105 G-protein coupled receptor 105 AXOR35 [ Show all ]
Disease	Allergic rhinitis Asthma Inflammatory disease Rheumatoid arthritis
Length	390
Amino acid sequence	MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
UniProt	Q9H3N8
Protein Data Bank	N/A
GPCR-HGmod model	Q9H3N8
3D structure model	This predicted structure model is from GPCR-EXP Q9H3N8.
BioLiP	N/A
Therapeutic Target Database	T26500
ChEMBL	CHEMBL3759
IUPHAR	265
DrugBank	BE0000146

Ligand

Name	4-[4-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]morpholine
Molecular formula	C14H23N5O
IUPAC name	4-[4-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]morpholine
Molecular weight	277.372
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	1.0
Synonyms	BAS 03357967 MLS000026829 2-(4-Morpholinyl)-4-methyl-6-(4-methyl-1-piperazinyl)pyrimidine STK537218 AC1LDH1N J3.528.915A Cambridge id 6742137 MolPort-001-848-275 ZINC73496 4-[4-Methyl-6-(4-methyl-piperazin-1-yl)-pyrimidin-2-yl]-morpholine CHEMBL1381010 AKOS000549556 MCULE-5478514203 CHEBI:109819 SMR000012255 HMS2179G22 [ Show all ]
Inchi Key	BMBIEKJDTGAZCY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H23N5O/c1-12-11-13(18-5-3-17(2)4-6-18)16-14(15-12)19-7-9-20-10-8-19/h11H,3-10H2,1-2H3
PubChem CID	647957
ChEMBL	CHEMBL1381010
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	6918.31 nM	MedChemComm, (2015) 6:6:1003	ChEMBL

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