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●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

BioLiP
Download all results in tab-seperated text for 903398 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
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  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    37001 1o95:B (3.7) BS02 ADP 1.5.8.2 GO:0009056 ... P16099 12567183
    37002 1o95:B (3.7) BS03 SF4 1.5.8.2 GO:0009056 ... P16099 12567183
    37003 1o95:C (3.7) BS01 AMP ? GO:0000166 ... P53570 12567183
    37004 1o95:E (3.7) BS01 AMP ? GO:0000166 ... P53570 12567183
    37005 1o96:A (3.1) BS01 AMP ? GO:0000166 ... P53570 12567183
    37006 1o96:A (3.1) BS02 FAD ? GO:0000166 ... P53570 12567183
    37007 1o96:B (3.1) BS01 FAD ? GO:0009055 ... P53571 12567183
    37008 1o96:C (3.1) BS01 AMP ? GO:0000166 ... P53570 12567183
    37009 1o96:C (3.1) BS02 FAD ? GO:0000166 ... P53570 12567183
    37010 1o96:D (3.1) BS01 FAD ? GO:0009055 ... P53571 12567183
    37011 1o96:E (3.1) BS01 AMP ? GO:0000166 ... P53570 12567183
    37012 1o96:E (3.1) BS02 FAD ? GO:0000166 ... P53570 12567183
    37013 1o96:F (3.1) BS01 FAD ? GO:0009055 ... P53571 12567183
    37014 1o96:Q (3.1) BS01 AMP ? GO:0000166 ... P53570 12567183
    37015 1o96:Z (3.1) BS01 FAD ? GO:0009055 ... P53571 12567183
    37016 1o97:C (1.6) BS01 AMP ? GO:0000166 ... P53570 12567183
    37017 1o97:C (1.6) BS02 FAD ? GO:0000166 ... P53570 12567183
    37018 1o97:D (1.6) BS01 FAD ? GO:0009055 ... P53571 12567183
    37019 1o98:A (1.4) BS01 MN 5.4.2.12 GO:0003824 ... Q9X519 12729763
    37020 1o98:A (1.4) BS02 MN 5.4.2.12 GO:0003824 ... Q9X519 12729763
    37021 1o98:A (1.4) BS03 2PG 5.4.2.12 GO:0003824 ... Q9X519 12729763
    37022 1o99:A (2.65) BS01 MN 5.4.2.12 GO:0003824 ... Q9X519 12729763
    37023 1o99:A (2.65) BS02 2PG 5.4.2.12 GO:0003824 ... Q9X519 12729763
    37024 1o9a:A (-1.00) BS01 peptide ? GO:0005576 ... P02751 12736686
    37025 1o9b:A (2.5) BS01 NAI 1.1.1.282 GO:0004764 ... P0A6D5 12637497
    37026 1o9b:B (2.5) BS01 NAI 1.1.1.282 GO:0004764 ... P0A6D5 12637497
    37027 1o9d:A (2.3) BS01 peptide ? GO:0005737 ... P93343 12606564
    37028 1o9e:A (2.6) BS01 FSC ? GO:0005737 ... P93343 12606564 PDBbind: -logKd/Ki=4.18, Kd=66uM
    37029 1o9f:A (2.7) BS01 peptide ? GO:0005737 ... P93343 12606564 Manual survey: Kd=0.7uM (12606564)
    37030 1o9f:A (2.7) BS02 FSC ? GO:0005737 ... P93343 12606564 Manual survey: Kd=0.7uM (12606564)
    37031 1o9i:A (1.33) BS01 MN3 1.11.1.6 GO:0004096 ... P60355 12631270
    37032 1o9i:A (1.33) BS02 MN3 1.11.1.6 GO:0004096 ... P60355 12631270
    37033 1o9i:A (1.33) BS03 CA 1.11.1.6 GO:0004096 ... P60355 12631270
    37034 1o9i:A (1.33) BS04 O 1.11.1.6 GO:0004096 ... P60355 12631270
    37035 1o9i:A (1.33) BS05 CA 1.11.1.6 GO:0004096 ... P60355 12631270
    37036 1o9i:B (1.33) BS01 MN3 1.11.1.6 GO:0004096 ... P60355 12631270
    37037 1o9i:B (1.33) BS02 MN3 1.11.1.6 GO:0004096 ... P60355 12631270
    37038 1o9i:B (1.33) BS03 CA 1.11.1.6 GO:0004096 ... P60355 12631270
    37039 1o9i:B (1.33) BS04 O 1.11.1.6 GO:0004096 ... P60355 12631270
    37040 1o9i:B (1.33) BS05 CA 1.11.1.6 GO:0004096 ... P60355 12631270
    37041 1o9i:C (1.33) BS01 CA 1.11.1.6 GO:0004096 ... P60355 12631270
    37042 1o9i:C (1.33) BS02 MN3 1.11.1.6 GO:0004096 ... P60355 12631270
    37043 1o9i:C (1.33) BS03 MN3 1.11.1.6 GO:0004096 ... P60355 12631270
    37044 1o9i:C (1.33) BS04 CA 1.11.1.6 GO:0004096 ... P60355 12631270
    37045 1o9i:C (1.33) BS05 O 1.11.1.6 GO:0004096 ... P60355 12631270
    37046 1o9i:D (1.33) BS01 MN3 1.11.1.6 GO:0004096 ... P60355 12631270
    37047 1o9i:D (1.33) BS02 MN3 1.11.1.6 GO:0004096 ... P60355 12631270
    37048 1o9i:D (1.33) BS03 CA 1.11.1.6 GO:0004096 ... P60355 12631270
    37049 1o9i:D (1.33) BS04 O 1.11.1.6 GO:0004096 ... P60355 12631270
    37050 1o9i:D (1.33) BS05 CA 1.11.1.6 GO:0004096 ... P60355 12631270
    37051 1o9i:E (1.33) BS01 CA 1.11.1.6 GO:0004096 ... P60355 12631270
    37052 1o9i:E (1.33) BS02 MN3 1.11.1.6 GO:0004096 ... P60355 12631270
    37053 1o9i:E (1.33) BS03 MN3 1.11.1.6 GO:0004096 ... P60355 12631270
    37054 1o9i:E (1.33) BS04 CA 1.11.1.6 GO:0004096 ... P60355 12631270
    37055 1o9i:E (1.33) BS05 O 1.11.1.6 GO:0004096 ... P60355 12631270
    37056 1o9i:F (1.33) BS01 CA 1.11.1.6 GO:0004096 ... P60355 12631270
    37057 1o9i:F (1.33) BS02 MN3 1.11.1.6 GO:0004096 ... P60355 12631270
    37058 1o9i:F (1.33) BS03 MN3 1.11.1.6 GO:0004096 ... P60355 12631270
    37059 1o9i:F (1.33) BS04 CA 1.11.1.6 GO:0004096 ... P60355 12631270
    37060 1o9i:F (1.33) BS05 O 1.11.1.6 GO:0004096 ... P60355 12631270
    37061 1o9j:A (2.4) BS01 NAD 1.2.1.3 GO:0001758 ... Q28399 12693930
    37062 1o9j:B (2.4) BS01 NAD 1.2.1.3 GO:0001758 ... Q28399 12693930
    37063 1o9j:C (2.4) BS01 NAD 1.2.1.3 GO:0001758 ... Q28399 12693930
    37064 1o9j:D (2.4) BS01 NAD 1.2.1.3 GO:0001758 ... Q28399 12693930
    37065 1o9k:A (2.6) BS01 peptide ? GO:0005634 ... P06400 12598654
    37066 1o9k:B (2.6) BS01 peptide ? GO:0005634 ... P06400 12598654
    37067 1o9k:C (2.6) BS01 peptide ? GO:0005634 ... P06400 12598654
    37068 1o9k:D (2.6) BS01 peptide ? GO:0005634 ... P06400 12598654
    37069 1o9k:E (2.6) BS01 peptide ? GO:0005634 ... P06400 12598654
    37070 1o9k:F (2.6) BS01 peptide ? GO:0005634 ... P06400 12598654
    37071 1o9k:G (2.6) BS01 peptide ? GO:0005634 ... P06400 12598654
    37072 1o9k:H (2.6) BS01 peptide ? GO:0005634 ... P06400 12598654
    37073 1o9l:A (2.4) BS01 EMT 2.8.3.5 GO:0005739 ... Q29551 N/A
    37074 1o9o:A (2.3) BS01 MLM ? GO:0003824 ... Q9ZIV5 12711609
    37075 1o9o:B (2.3) BS01 MLM ? GO:0003824 ... Q9ZIV5 12711609
    37076 1o9s:A (1.75) BS01 peptide 2.1.1.364 GO:0005694 ... Q8WTS6 12540855
    37077 1o9s:A (1.75) BS02 SAH 2.1.1.364 GO:0005694 ... Q8WTS6 12540855
    37078 1o9s:B (1.75) BS01 peptide 2.1.1.364 GO:0005694 ... Q8WTS6 12540855
    37079 1o9s:B (1.75) BS02 peptide 2.1.1.364 GO:0005694 ... Q8WTS6 12540855
    37080 1o9s:B (1.75) BS03 SAH 2.1.1.364 GO:0005694 ... Q8WTS6 12540855
    37081 1o9t:A (2.9) BS01 MET 2.5.1.6 GO:0000287 ... P13444 12888348
    37082 1o9t:A (2.9) BS02 MG 2.5.1.6 GO:0000287 ... P13444 12888348
    37083 1o9t:A (2.9) BS03 ATP 2.5.1.6 GO:0000287 ... P13444 12888348
    37084 1o9t:B (2.9) BS01 ATP 2.5.1.6 GO:0000287 ... P13444 12888348
    37085 1o9t:B (2.9) BS02 PO4 2.5.1.6 GO:0000287 ... P13444 12888348
    37086 1o9u:A (2.4) BS01 peptide 2.7.11.1
    2.7.11.26    		 GO:0004672 ... P49841 12554650
    37087 1o9u:A (2.4) BS02 ADZ 2.7.11.1
    2.7.11.26    		 GO:0004672 ... P49841 12554650
    37088 1o9v:A (1.75) BS01 SNG ? GO:0009289 ... Q99003 12864853
    37089 1o9w:A (1.65) BS01 NAG ? GO:0009289 ... Q99003 12864853 MOAD: Kd=1.18mM
    37090 1o9x:A (3.2) BS01 HEM ? GO:0003677 ... P02768 12846933
    37091 1oa0:A (1.25) BS01 SF4 1.7.99.1 GO:0003824 ... Q01770 12764602
    37092 1oa0:A (1.25) BS02 SF3 1.7.99.1 GO:0003824 ... Q01770 12764602
    37093 1oa0:B (1.25) BS01 SF4 1.7.99.1 GO:0003824 ... Q01770 12764602
    37094 1oa0:B (1.25) BS02 SF3 1.7.99.1 GO:0003824 ... Q01770 12764602
    37095 1oa1:A (1.55) BS01 SF4 1.7.99.1 GO:0003824 ... P31101 12764602
    37096 1oa1:A (1.55) BS02 SF3 1.7.99.1 GO:0003824 ... P31101 12764602
    37097 1oa7:A (2.0) BS01 BGC 3.2.1.4 GO:0005975 ... Q8J0K8 12767825
    37098 1oa7:A (2.0) BS02 BGC 3.2.1.4 GO:0005975 ... Q8J0K8 12767825
    37099 1oaa:A (1.25) BS01 OAA 1.1.1.153 GO:0004757 ... Q64105 9405351
    37100 1oaa:A (1.25) BS02 NAP 1.1.1.153 GO:0004757 ... Q64105 9405351
    37101 1oab:A (1.9) BS01 MN 2.5.1.54 GO:0003849 ... P32449 15019786
    37102 1oab:A (1.9) BS02 PEP 2.5.1.54 GO:0003849 ... P32449 15019786
    37103 1oab:B (1.9) BS01 MN 2.5.1.54 GO:0003849 ... P32449 15019786
    37104 1oab:B (1.9) BS02 PEP 2.5.1.54 GO:0003849 ... P32449 15019786
    37105 1oac:A (2.0) BS01 CU 1.4.3.21 GO:0005507 ... P46883 8591028
    37106 1oac:A (2.0) BS02 CA 1.4.3.21 GO:0005507 ... P46883 8591028
    37107 1oac:A (2.0) BS03 CA 1.4.3.21 GO:0005507 ... P46883 8591028
    37108 1oac:B (2.0) BS01 CU 1.4.3.21 GO:0005507 ... P46883 8591028
    37109 1oac:B (2.0) BS02 CA 1.4.3.21 GO:0005507 ... P46883 8591028
    37110 1oac:B (2.0) BS03 CA 1.4.3.21 GO:0005507 ... P46883 8591028
    37111 1oad:A (1.5) BS01 MN 5.3.1.5 GO:0000287 ... P24300 12777803
    37112 1oad:A (1.5) BS02 MG 5.3.1.5 GO:0000287 ... P24300 12777803
    37113 1oad:A (1.5) BS03 MQD 5.3.1.5 GO:0000287 ... P24300 12777803
    37114 1oad:B (1.5) BS01 MN 5.3.1.5 GO:0000287 ... P24300 12777803
    37115 1oad:B (1.5) BS02 MG 5.3.1.5 GO:0000287 ... P24300 12777803
    37116 1oad:B (1.5) BS03 MQD 5.3.1.5 GO:0000287 ... P24300 12777803
    37117 1oae:A (1.95) BS01 HEC ? GO:0003674 ... Q9RQB9 16341897
    37118 1oae:B (1.95) BS01 HEC ? GO:0003674 ... Q9RQB9 16341897
    37119 1oaf:A (1.4) BS01 HEM 1.11.1.11 GO:0004601 ... Q43758 12640445
    37120 1oaf:A (1.4) BS02 ASC 1.11.1.11 GO:0004601 ... Q43758 12640445
    37121 1oag:A (1.75) BS01 HEM 1.11.1.11 GO:0004601 ... Q43758 12640445
    37122 1oah:A (2.3) BS01 HEC 1.7.2.2 GO:0042279 ... Q8VNU2 12618432
    37123 1oah:A (2.3) BS02 HEC 1.7.2.2 GO:0042279 ... Q8VNU2 12618432
    37124 1oah:A (2.3) BS03 HEC 1.7.2.2 GO:0042279 ... Q8VNU2 12618432
    37125 1oah:A (2.3) BS04 HEC 1.7.2.2 GO:0042279 ... Q8VNU2 12618432
    37126 1oah:A (2.3) BS05 HEC 1.7.2.2 GO:0042279 ... Q8VNU2 12618432
    37127 1oah:A (2.3) BS06 CA 1.7.2.2 GO:0042279 ... Q8VNU2 12618432
    37128 1oah:A (2.3) BS07 CA 1.7.2.2 GO:0042279 ... Q8VNU2 12618432
    37129 1oah:A (2.3) BS08 ZN 1.7.2.2 GO:0042279 ... Q8VNU2 12618432
    37130 1oah:A (2.3) BS09 HEC 1.7.2.2 GO:0042279 ... Q8VNU2 12618432
    37131 1oah:B (2.3) BS01 HEC 1.7.2.2 GO:0042279 ... Q8VNU2 12618432
    37132 1oah:B (2.3) BS02 HEC 1.7.2.2 GO:0042279 ... Q8VNU2 12618432
    37133 1oah:B (2.3) BS03 HEC 1.7.2.2 GO:0042279 ... Q8VNU2 12618432
    37134 1oah:B (2.3) BS04 HEC 1.7.2.2 GO:0042279 ... Q8VNU2 12618432
    37135 1oah:B (2.3) BS05 HEC 1.7.2.2 GO:0042279 ... Q8VNU2 12618432
    37136 1oah:B (2.3) BS06 HEC 1.7.2.2 GO:0042279 ... Q8VNU2 12618432
    37137 1oah:B (2.3) BS07 CA 1.7.2.2 GO:0042279 ... Q8VNU2 12618432
    37138 1oah:B (2.3) BS08 CA 1.7.2.2 GO:0042279 ... Q8VNU2 12618432
    37139 1oai:A (1.0) BS01 peptide ? GO:0005634 ... Q9UBU9 12581645
    37140 1oaj:A (1.73) BS01 ZN 1.15.1.1 GO:0004784 ... P00446 12595249
    37141 1oaj:A (1.73) BS02 CU 1.15.1.1 GO:0004784 ... P00446 12595249
    37142 1oal:A (1.5) BS01 ZN 1.15.1.1 GO:0004784 ... P00446 12595249
    37143 1oal:A (1.5) BS02 CU 1.15.1.1 GO:0004784 ... P00446 12595249
    37144 1oan:A (2.75) BS01 FUC 2.1.1.56
    2.1.1.57
    2.7.7.48
    3.4.21.91
    3.6.1.15
    3.6.4.13    		 GO:0046983 ... P12823 12759475
    37145 1oan:B (2.75) BS01 FUC 2.1.1.56
    2.1.1.57
    2.7.7.48
    3.4.21.91
    3.6.1.15
    3.6.4.13    		 GO:0046983 ... P12823 12759475
    37146 1oao:A (1.9) BS01 SF4 1.2.7.4 GO:0003824 ... P27989 12627225
    37147 1oao:A (1.9) BS02 XCC 1.2.7.4 GO:0003824 ... P27989 12627225
    37148 1oao:A (1.9) BS03 FE2 1.2.7.4 GO:0003824 ... P27989 12627225
    37149 1oao:A (1.9) BS04 SF4 1.2.7.4 GO:0003824 ... P27989 12627225
    37150 1oao:B (1.9) BS01 SF4 1.2.7.4 GO:0003824 ... P27989 12627225
    37151 1oao:B (1.9) BS02 SF4 1.2.7.4 GO:0003824 ... P27989 12627225
    37152 1oao:B (1.9) BS03 XCC 1.2.7.4 GO:0003824 ... P27989 12627225
    37153 1oao:B (1.9) BS04 BCT 1.2.7.4 GO:0003824 ... P27989 12627225
    37154 1oao:B (1.9) BS05 FE2 1.2.7.4 GO:0003824 ... P27989 12627225
    37155 1oao:C (1.9) BS01 SF4 2.3.1.169 GO:0003824 ... P27988 12627225
    37156 1oao:C (1.9) BS02 ZN 2.3.1.169 GO:0003824 ... P27988 12627225
    37157 1oao:D (1.9) BS01 SF4 2.3.1.169 GO:0003824 ... P27988 12627225
    37158 1oar:H (2.23) BS01 AZN N/A N/A N/A 12610298 MOAD: Kd=40nM
    PDBbind: -logKd/Ki=7.40, Kd=40nM
    37159 1oar:I (2.23) BS01 AZN N/A N/A N/A 12610298 MOAD: Kd=40nM
    37160 1oar:J (2.23) BS01 AZN N/A N/A N/A 12610298 MOAD: Kd=40nM
    37161 1oar:K (2.23) BS01 AZN N/A N/A N/A 12610298 MOAD: Kd=40nM
    37162 1oar:L (2.23) BS01 AZN ? GO:0002250 ... P01724 12610298 PDBbind: -logKd/Ki=7.40, Kd=40nM
    37163 1oar:M (2.23) BS01 AZN ? GO:0002250 ... P01724 12610298
    37164 1oar:N (2.23) BS01 AZN ? GO:0002250 ... P01724 12610298
    37165 1oar:O (2.23) BS01 AZN ? GO:0002250 ... P01724 12610298
    37166 1oas:A (2.2) BS01 PLP 2.5.1.47 GO:0004124 ... P0A1E3 9761678
    37167 1oas:B (2.2) BS01 PLP 2.5.1.47 GO:0004124 ... P0A1E3 9761678
    37168 1oat:A (2.5) BS01 PLP 2.6.1.13 GO:0004587 ... P04181 9514741
    37169 1oat:B (2.5) BS01 PLP 2.6.1.13 GO:0004587 ... P04181 9514741
    37170 1oat:C (2.5) BS01 PLP 2.6.1.13 GO:0004587 ... P04181 9514741
    37171 1oau:H (1.8) BS01 DNF N/A N/A N/A 12610298 PDBbind: -logKd/Ki=7.70, Kd=20nM
    37172 1oau:J (1.8) BS01 DNF N/A N/A N/A 12610298
    37173 1oau:L (1.8) BS01 DNF ? GO:0002250 ... P01724 12610298 PDBbind: -logKd/Ki=7.70, Kd=20nM
    37174 1oau:M (1.8) BS01 peptide ? GO:0002250 ... P01724 12610298
    37175 1oau:N (1.8) BS01 DNF ? GO:0002250 ... P01724 12610298
    37176 1oau:O (1.8) BS01 peptide ? GO:0002250 ... P01724 12610298
    37177 1oax:H (2.67) BS01 ANQ N/A N/A N/A 12610298
    37178 1oax:J (2.67) BS01 ANQ N/A N/A N/A 12610298
    37179 1oay:H (2.66) BS01 FUR N/A N/A N/A 12610298 PDBbind: -logKd/Ki=5.92, Kd=1.2uM
    37180 1oay:J (2.66) BS01 FUR N/A N/A N/A 12610298
    37181 1oay:L (2.66) BS01 FUR ? GO:0002250 ... P01724 12610298 PDBbind: -logKd/Ki=5.92, Kd=1.2uM
    37182 1oay:N (2.66) BS01 FUR ? GO:0002250 ... P01724 12610298
    37183 1ob0:A (1.83) BS01 CA 3.2.1.1 GO:0004553 ... P06278 12540849
    37184 1ob0:A (1.83) BS02 CA 3.2.1.1 GO:0004553 ... P06278 12540849
    37185 1ob0:A (1.83) BS03 CA 3.2.1.1 GO:0004553 ... P06278 12540849
    37186 1ob2:A (3.35) BS01 rna 3.6.1.48 GO:0003723 ... P0CE48 N/A
    37187 1ob2:A (3.35) BS02 GLC 3.6.1.48 GO:0003723 ... P0CE48 N/A
    37188 1ob2:A (3.35) BS03 FRU 3.6.1.48 GO:0003723 ... P0CE48 N/A
    37189 1ob2:A (3.35) BS04 KIR 3.6.1.48 GO:0003723 ... P0CE48 N/A
    37190 1ob2:A (3.35) BS05 GNP 3.6.1.48 GO:0003723 ... P0CE48 N/A
    37191 1ob2:A (3.35) BS06 MG 3.6.1.48 GO:0003723 ... P0CE48 N/A
    37192 1ob5:A (3.1) BS01 rna 3.6.1.48 GO:0003746 ... Q01698 16257965
    37193 1ob5:A (3.1) BS02 rna 3.6.1.48 GO:0003746 ... Q01698 16257965
    37194 1ob5:A (3.1) BS03 GNP 3.6.1.48 GO:0003746 ... Q01698 16257965
    37195 1ob5:A (3.1) BS04 MG 3.6.1.48 GO:0003746 ... Q01698 16257965
    37196 1ob5:A (3.1) BS05 ENX 3.6.1.48 GO:0003746 ... Q01698 16257965
    37197 1ob5:C (3.1) BS01 rna 3.6.1.48 GO:0003746 ... Q01698 16257965
    37198 1ob5:C (3.1) BS02 rna 3.6.1.48 GO:0003746 ... Q01698 16257965
    37199 1ob5:C (3.1) BS03 GNP 3.6.1.48 GO:0003746 ... Q01698 16257965
    37200 1ob5:C (3.1) BS04 MG 3.6.1.48 GO:0003746 ... Q01698 16257965
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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