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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	leukotriene D4
Molecular formula	C25H40N2O6S
IUPAC name	(5S,6R,7E,9E,11Z,14Z)-6-[2-amino-3-(carboxymethylamino)-3-oxopropyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid
Molecular weight	496.663
Hydrogen bond acceptor	8
Hydrogen bond donor	5
XlogP	1.4
Synonyms	27833-EP2308509A1 27833-EP2374787A1 BML1-E08 Leukotriene D(sub 4) SCHEMBL4295683 27833-EP2272849A1 27833-EP2292592A1 27833-EP2309584A1 D0B2WI LTD [3H]-LTD4 (5S,6R,7E,9E,11Z,14Z)-6-({2-amino-2-[(carboxymethyl)carbamoyl]ethyl}sulfanyl)-5-hydroxyicosa-7,9,11,14-tetraenoic acid 27833-EP2305254A1 27833-EP2371811A2 73836-78-9 GTPL3353 NCGC00161277-01 27833-EP2270113A1 27833-EP2289882A1 27833-EP2308857A1 27833-EP2374788A1 CHEMBL1521056 SMP2_000046 27833-EP2295406A1 27833-EP2314587A1 DTXSID6040533 LTD (sub 4) [3H]LTD4 (5S,6R,7E,9E,11Z,14Z)-6-[2-amino-3-(carboxymethylamino)-3-oxopropyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid 27833-EP2305627A1 27833-EP2372017A1 AC1O5JI4 GTPL3412 S-[(4S,5R,6E,8E,10Z,13Z)-1-carboxy-4-hydroxynonadeca-6,8,10,13-tetraen-5-yl]cysteinylglycine 27833-EP2270114A1 27833-EP2289886A1 27833-EP2308865A1 27833-EP2374895A1 D03YBH LS-72362 YEESKJGWJFYOOK-LDDGIIIKSA-N 27833-EP2298767A1 27833-EP2371810A1 5(S)-Hydroxy-6(R)-S-cysteinylglycinyl-7-trans-9-trans-11-cis-14-cis-eicosatetraenoic Acid Glycine, N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-L-cysteinyl)-, (R-(R,S-(E,E,Z,Z)))- LTD4 27833-EP2270101A1 [ Show all ]
Inchi Key	YEESKJGWJFYOOK-LDDGIIIKSA-N
Inchi ID	InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20?,21-,22+/m0/s1
PubChem CID	6435286
ChEMBL	N/A
IUPHAR	3353, 3412
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
555315	Cysteinyl leukotriene receptor 1	Q9Y271	CYSLTR1	Homo sapiens (Human)	337
555316	Cysteinyl leukotriene receptor 2	Q9NS75	CYSLTR2	Homo sapiens (Human)	346
555317	Uracil nucleotide/cysteinyl leukotriene receptor	Q6NS65	Gpr17	Mus musculus (Mouse)	339
555318	Uracil nucleotide/cysteinyl leukotriene receptor	Q13304	GPR17	Homo sapiens (Human)	367

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