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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	NAFARELIN
Molecular formula	C66H83N17O13
IUPAC name	(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Molecular weight	1322.5
Hydrogen bond acceptor	15
Hydrogen bond donor	16
XlogP	0.8
Synonyms	CN-156 MolPort-006-823-890 Nafareline Synarel (TN) 76932-60-0 (monoacetate (salt)) AKOS015895038 DB00666 NAFARELIN ACETATE Nafarelinum [Latin] (D-2-Nal6)-LHRH BIDD:GT0760 LHRH, Ala(2-naphthyl)(6)- Nafarelina SCHEMBL22518 6-(3-(2-Naphthalenyl)-D-alanine)luteinizing hormone-releasing factor (pig) 86220-42-0 (acetate (salt), hydrate) D08WYM Nafareline [French] UNII-1X0094V6JV AKOS030529554 HS-2018 Nafarelin Acetate, Hydrate RS-94991-298 (S)-1-((3S,6S,9S,12S,15R,18S,21S)-3-((1H-imidazol-5-yl)methyl)-6-((1H-indol-3-yl)methyl)-21-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-(hydroxymethyl)-18-isobutyl-15-(naphthalen-2-ylmethyl)-1,4,7,10,13,16,19-heptaoxo-1-((S)-5-oxopyrrolidin-2-yl)-2,5,8,11, C66H83N17O13 Luteinizing hormone-releasing factor (pig), 6-(3-(2-naphthalenyl)-D-alanine)- Nafarelina [Spanish] Synarel 76932-56-4 932N564 Nafarelin (INN) Nafarelinum BDBM84707 K335 Nafarelin [INN:BAN] SC-17368 1X0094V6JV [ Show all ]
Inchi Key	RWHUEXWOYVBUCI-ITQXDASVSA-N
Inchi ID	InChI=1S/C66H83N17O13/c1-36(2)25-48(58(89)76-47(13-7-23-71-66(68)69)65(96)83-24-8-14-54(83)64(95)73-33-55(67)86)77-60(91)50(28-38-15-18-39-9-3-4-10-40(39)26-38)78-59(90)49(27-37-16-19-43(85)20-17-37)79-63(94)53(34-84)82-61(92)51(29-41-31-72-45-12-6-5-11-44(41)45)80-62(93)52(30-42-32-70-35-74-42)81-57(88)46-21-22-56(87)75-46/h3-6,9-12,15-20,26,31-32,35-36,46-54,72,84-85H,7-8,13-14,21-25,27-30,33-34H2,1-2H3,(H2,67,86)(H,70,74)(H,73,95)(H,75,87)(H,76,89)(H,77,91)(H,78,90)(H,79,94)(H,80,93)(H,81,88)(H,82,92)(H4,68,69,71)/t46-,47-,48-,49-,50+,51-,52-,53-,54-/m0/s1
PubChem CID	25077405
ChEMBL	N/A
IUPHAR	N/A
BindingDB	N/A
DrugBank	DB00666
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
551721	Gonadotropin-releasing hormone receptor	P30968	GNRHR	Homo sapiens (Human)	328
551720	Putative gonadotropin-releasing hormone II receptor	Q96P88	GNRHR2	Homo sapiens (Human)	292

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