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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	physostigmine
Molecular formula	C15H21N3O2
IUPAC name	[(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-methylcarbamate
Molecular weight	275.352
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	0.7
Synonyms	Pyrrolo[2, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)- Spectrum4_000997 EU-0100483 SPBio_000774 SR-01000075341-1 HMS3261B07 ZINC91689892 KBio2_006532 (3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-ol methylcarbamate (ester) KBioSS_002279 AC1L1LJL Methyl-carbamic acid, ester with eseroline BDBM11023 NCGC00093889-06 BSPBio_002189 NCGC00261168-01 CHEBI:27953 Physostigmine (local acting gel, xerostomia) DB00981 Prestwick0_000566 Erserine SBI-0050467.P004 Spectrum5_000441 Fysostigmin [Czech] SpecPlus_000381 Tox21_301591 KBio1_001421 (-)-physostigmine KBio3_001842 50975-37-6 LS-109562 AJ-86526 NCGC00093889-01 BPBio1_000388 NCGC00093889-09 Carbamic acid, ester with eseroline NSC-30782 CHEMBL94 Physostigmine [USAN:BAN] DSSTox_GSID_23471 Prestwick3_000566 Spectrum2_000330 Eserine sulfate Spectrum3_000545 Eserolein, methylcarbamate (ester) SMR000718753 Spectrum_000916 HMS2089M11 WLN: T B556 EN GNTT&J B1 E1 G1 KOVM1 KBio2_003964 (3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyrrolo[2,3-b]indol-5-yl N-methylcarbamate KBioGR_002533 9U1VM840SP MCV 4484 AX8147965 NCGC00093889-04 BRD-K25650355-059-12-2 NCGC00093889-13 CCG-38605 D00196 Physostol E 8375 Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis) RCRA waste no. P204 Spectrum4_001631 Ezerin SPBio_001285 Tox21_111228 HSDB 3161 [(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-methylcarbamate KBio2_007414 1,2,3,3abeta,8abeta-Hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)-indol-5-yl methylcarbamate Lopac0_000483 Acetylcholinesterase inhibitor (dry mouth), Calabar MLS001304022 BDBM50004000 NCGC00093889-07 C06535 NIH 10421 CHEMBL537674 Physostigmine (local acting gel, xerostomia), Calabar DivK1c_006477 Prestwick1_000566 Eserine Eserine, >=98.0% (N) SCHEMBL24044 Spectrum5_000626 GTPL6598 SPECTRUM1500753 Tox21_500483 KBio2_001396 (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl methylcarbamate KBioGR_001433 511-49-9 MCULE-2638001883 Antilirium NCGC00093889-02 BRD-K25650355-001-02-5 NCGC00093889-10 Carbamic acid, methyl-, ester with eseroline NSC30782 cid_657348 Physostigmine [USP:BAN] DSSTox_RID_77040 Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, 5-(N-methylcarbamate), (3aS,8aR)- Spectrum2_000757 Spectrum3_000901 Esromiotin SPBio_000339 Spectrum_001789 HMS2236L08 Xalieve KBio2_004846 (3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyrrolo[2,3-b]indol-5-yl N-methylcarbamate; 2-hydroxybenzoic acid KBioSS_001396 AC-15983 MEGxp0_001872 BCP19735 NCGC00093889-05 BSPBio_000352 NCGC00255345-01 CCRIS 3422 Physostigmine (buccal, xerostomia), Calabar D09JVV PIJVFDBKTWXHHD-HIFRSBDPSA-N EINECS 200-332-8 Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)- RP29728 Spectrum4_001913 Fysostigmin SPBio_002571 Tox21_111228_1 KB-207147 (-) physostigmine KBio3_001689 LP00483 ACon1_000097 MolPort-001-683-926 BDBM50222010 NCGC00093889-08 Calabarine NSC 30782 Physostigmine (USP) DSSTox_CID_3471 Prestwick2_000566 Eserine (TN) Eserolein, methylcarbamate SDCCGMLS-0066585.P001 Spectrum5_001672 HMS1921G06 UNII-9U1VM840SP KBio2_002278 (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl methylcarbamate hydrochloride KBioGR_002061 57-47-6 MCULE-9310809074 API0003840 NCGC00093889-03 BRD-K25650355-059-02-3 NCGC00093889-12 CAS-57-47-6 P0406 CS 58525 physostigmine.salicylic acid DTXSID3023471 Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS,8aR)- Spectrum2_001283 [ Show all ]
Inchi Key	PIJVFDBKTWXHHD-HIFRSBDPSA-N
Inchi ID	InChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1
PubChem CID	5983
ChEMBL	CHEMBL94
IUPHAR	N/A
BindingDB	50004000
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
260545	Muscarinic acetylcholine receptor M1	P12657	Chrm1	Mus musculus (Mouse)	460
260546	Muscarinic acetylcholine receptor M2	P10980	Chrm2	Rattus norvegicus (Rat)	466
260547	Muscarinic acetylcholine receptor M2	Q9ERZ4	Chrm2	Mus musculus (Mouse)	466

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