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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Neuropeptide FF
Molecular formula	C54H76N14O10
IUPAC name	(2S)-2-[[(2S)-1-[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pentanediamide
Molecular weight	1081.29
Hydrogen bond acceptor	12
Hydrogen bond donor	12
XlogP	-0.3
Synonyms	Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe amide, >=95% (HPLC) B5386 MFCD00076704 CAS_235433-36-0 NEUROPEPTIDE FF MORPHINE MODULATING NEUROPEPTIDE 2-{[1-(2-{2-[2-(2-Amino-3-phenyl-propionylamino)-4-methyl-pentanoylamino]-3-phenyl-propionylamino}-4-carbamoyl-butyryl)-pyrrolidine-2-carbonyl]-amino}-pentanedioic acid 5-amide 1-{[1-(1-carbamoyl-2-phenyl-ethylcarbamoyl)-4-guanidino-butyl]-amide} 99566-27-5 CHEMBL429731 phe-leu-phe-gln-pro-gln-arg-phe-amide BDBM50037557 NCGC00167257-01 CAS_99566-27-5 Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe amide AKOS024457451 F-8-F-NH2 PrRP31 BDBM86139 [ Show all ]
Inchi Key	HWYCFZUSOBOBIN-AQJXLSMYSA-N
Inchi ID	InChI=1S/C54H76N14O10/c1-32(2)28-41(66-47(72)36(55)29-33-14-6-3-7-15-33)50(75)67-42(31-35-18-10-5-11-19-35)51(76)64-39(23-25-45(57)70)53(78)68-27-13-21-43(68)52(77)63-38(22-24-44(56)69)49(74)62-37(20-12-26-61-54(59)60)48(73)65-40(46(58)71)30-34-16-8-4-9-17-34/h3-11,14-19,32,36-43H,12-13,20-31,55H2,1-2H3,(H2,56,69)(H2,57,70)(H2,58,71)(H,62,74)(H,63,77)(H,64,76)(H,65,73)(H,66,72)(H,67,75)(H4,59,60,61)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
PubChem CID	9854861
ChEMBL	CHEMBL429731
IUPHAR	N/A
BindingDB	86139, 50037557
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
125941	Neuropeptide FF receptor 2	Q9EQD2	Npffr2	Rattus norvegicus (Rat)	417
478470	Neuropeptide FF receptor 2	Q9Y5X5	NPFFR2	Homo sapiens (Human)	522
555978	Prolactin-releasing peptide receptor	P49683	PRLHR	Homo sapiens (Human)	370

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