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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	RY-764
Molecular formula	C34H51FN4O3
IUPAC name	(1R,4S,6R)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide
Molecular weight	582.805
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	5.4
Synonyms	GTPL1337 SCHEMBL14040521 Anti-obesity therapy, Merck &Co Melanocortin agonists (obesity/erectile dysfunction), Merck & Co (1R,4S,6R)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-7-methyl-7-azabicyclo[2.2.2]octane-6-carboxamide CHEMBL364346 MC4 receptor agonists (obesity) BDBM50169442 MZ-767 (1S,4R,5R)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-3-methyl-3-azabicyclo[2.2.2]octane-5-carboxamide D0N6KO RY764 AC1OCFYT MC4 receptor agonists (obesity), Merck & Co (1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide RY 764 [ Show all ]
Inchi Key	ARFBDECCXOFCBN-HOLBEBDISA-N
Inchi ID	InChI=1S/C34H51FN4O3/c1-33(2,3)37-32(42)34(25-8-6-5-7-9-25)16-18-39(19-17-34)31(41)28(21-23-10-13-26(35)14-11-23)36-30(40)27-20-24-12-15-29(27)38(4)22-24/h10-11,13-14,24-25,27-29H,5-9,12,15-22H2,1-4H3,(H,36,40)(H,37,42)/t24-,27+,28+,29+/m0/s1
PubChem CID	6918851
ChEMBL	CHEMBL364346
IUPHAR	1337
BindingDB	50169442
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
12401	Adrenocorticotropic hormone receptor	Q01718	MC2R	Homo sapiens (Human)	297
12400	Melanocortin receptor 3	P41968	MC3R	Homo sapiens (Human)	323
12396	Melanocortin receptor 4	P56450	Mc4r	Mus musculus (Mouse)	332
12397	Melanocortin receptor 4	P32245	MC4R	Homo sapiens (Human)	332
12399	Melanocortin receptor 4	P70596	Mc4r	Rattus norvegicus (Rat)	332
12398	Melanocortin receptor 5	P33032	MC5R	Homo sapiens (Human)	325
12402	Melanocyte-stimulating hormone receptor	Q01726	MC1R	Homo sapiens (Human)	317

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