Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

You can:

Check the GPCR table for details.
Go to the ligand list to see ligands that interacts with this GPCR.
Go to the individual ligand page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

GPCR

Name	KiSS-1 receptor
Species	Homo sapiens (Human)
Gene	KISS1R
Synonym	Metastin receptor Kisspeptins receptor kisspeptin receptor KiSS1-derived peptide receptor KiSS-1R kiSS-1 receptor Hypogonadotropin-1 hOT7T175 GPR54 G-protein coupled receptor OT7T175 G-protein coupled receptor 54 [ Show all ]
Disease	Prostate cancer
Length	398
Amino acid sequence	MHTVATSGPNASWGAPANASGCPGCGANASDGPVPSPRAVDAWLVPLFFAALMLLGLVGNSLVIYVICRHKPMRTVTNFYIANLAATDVTFLLCCVPFTALLYPLPGWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLALHRLSPGPRAYCSEAFPSRALERAFALYNLLALYLLPLLATCACYAAMLRHLGRVAVRPAPADSALQGQVLAERAGAVRAKVSRLVAAVVLLFAACWGPIQLFLVLQALGPAGSWHPRSYAAYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRVCPCAPRRPRRPRRPGPSDPAAPHAELLRLGSHPAPARAQKPGSSGLAARGLCVLGEDNAPL
UniProt	Q969F8
Protein Data Bank	N/A
GPCR-HGmod model	Q969F8
3D structure model	This predicted structure model is from GPCR-EXP Q969F8.
BioLiP	N/A
Therapeutic Target Database	T39123
ChEMBL	CHEMBL5413
IUPHAR	266
DrugBank	N/A

Known ligands

You can:

Click GLASS IDs to check the association information.
Click ligand names to check details of the ligands.
Download a TSV version of all interaction information.
Download a SDF structure collection of all known ligands.

GLASS ID	Molecule	Formula	Molecular weight	H-bond acceptor / donor	XlogP	Lipinski's druglikeness
225	BDBM50203786	C75H105N23O18	1616.81	21 / 22	-4.4	No
513	CHEMBL3085807	C60H88N18O13	1269.48	16 / 17	-1.1	No
441715	CHEMBL3314214	C60H79N17O12	1230.4	15 / 16	-0.3	No
2028	BDBM50203804	C75H110N24O18	1635.85	21 / 23	-5.7	No
2353	CHEMBL385105	C75H100N18O18	1541.73	19 / 19	-1.7	No
5264	CHEMBL268659	C40H51N11O6	781.919	8 / 9	1.2	No
536077	CHEMBL3928465	C64H82FN17O13	1316.46	15 / 18	1.3	No
7154	CHEMBL2152060	C64H85N17O14	1316.49	16 / 18	-1.5	No
9911	CHEMBL218690	C30H23N5O2S	517.607	5 / 2	4.4	No
557623	CHEMBL1171102	C28H22FN5O4	511.513	8 / 4	4.0	No
548024	CHEMBL3982675	C59H82N16O13	1223.4	14 / 16	-0.3	No
14530	CHEMBL440431	C44H57N11O7	852.01	8 / 10	1.4	No
14919	CHEMBL229621	C43H57N13O6	852.014	8 / 11	0.7	No
14929	LPNYNWNSFGLRF	C78H106N20O19	1627.83	21 / 21	-4.5	No
557694	CHEMBL1171104	C29H26FN5O4	527.556	8 / 4	4.8	No
15515	CHEMBL373854	C82H106N18O18	1631.86	19 / 19	0.3	No
442501	CHEMBL3314224	C64H83N17O13	1298.47	14 / 18	1.2	No
548126	CHEMBL3985112	C64H83N17O13	1298.47	14 / 18	1.2	No
21187	CHEMBL226537	C41H52N10O9	828.928	10 / 12	1.2	No
25492	CHEMBL388146	C41H51N11O8	825.928	9 / 9	2.1	No
536713	CHEMBL3977314	C58H79FN16O15	1259.36	17 / 18	-1.0	No
442825	CHEMBL3314227	C69H85N17O13	1360.55	14 / 19	3.1	No
558169	CHEMBL1163808	C31H29N5O4	535.604	7 / 4	4.1	No
558279	CHEMBL1171296	C30H26FN5O4	539.567	8 / 3	4.8	No
442956	CHEMBL3422510	C69H93N17O16	1416.61	17 / 20	-0.1	No
34714	CHEMBL221764	C78H106N20O19	1627.83	20 / 21	-2.6	No
443045	CHEMBL3422010	C21H19N5OS2	421.537	6 / 0	3.0	Yes
558361	CHEMBL1171797	C32H32FN5O4	569.637	8 / 3	5.6	No
35758	CID 44419669	C78H107N21O18	1626.84	20 / 22	-2.2	No
36177	BDBM50203780	C75H101N21O18	1584.76	20 / 21	-4.2	No
36834	CHEMBL2151645	C64H85N17O14	1316.49	16 / 18	-1.2	No
443161	CHEMBL3422516	C89H128N20O18	1766.12	21 / 21	6.5	No
536952	CHEMBL3939287	C55H75FN16O13	1187.3	15 / 17	-0.9	No
536984	CHEMBL3985323	C56H78N16O13	1183.34	14 / 17	-1.1	No
443244	CHEMBL3422407	C65H85N17O16	1360.5	17 / 20	-1.9	No
40352	CHEMBL3087930	C56H81N17O15	1232.37	17 / 19	-3.8	No
40353	CHEMBL2151648	C56H81N17O15	1232.37	17 / 19	-3.8	No
558540	CHEMBL1165103	C27H23N5O4S	513.572	8 / 4	3.9	No
537091	CHEMBL3931718	C57H78N16O13	1195.35	14 / 16	-1.1	No
43464	CHEMBL3645505	C10H20N2O2	200.282	3 / 2	0.6	Yes
43465	CHEMBL3645498	C10H20N2O2	200.282	3 / 2	0.6	Yes
43520	BDBM50203814	C79H109N21O18	1640.87	20 / 21	-2.1	No
443576	CHEMBL3314225	C66H87N17O13	1326.53	14 / 18	2.0	No
49372	CHEMBL388586	C41H51FN10O6	798.921	8 / 9	2.4	No
49375	Peptide analogue, 26	C41H51FN10O6	798.921	8 / 9	2.4	No
56872	CHEMBL389708	C41H52N10O7	796.93	8 / 10	1.9	No
444023	CHEMBL3422511	C70H94N18O16	1443.63	17 / 20	-0.8	No
444065	CHEMBL3422018	C20H18N6OS2	422.525	7 / 0	2.8	Yes
62321	CHEMBL2151651	C60H82N18O14	1279.43	17 / 18	-2.6	No
444203	CHEMBL3422410	C67H85N21O14	1408.55	19 / 18	-1.5	No
559331	CHEMBL1169893	C27H23N5O3S	497.573	7 / 3	4.5	Yes
559441	CHEMBL1164988	C26H20ClN5O3S	517.988	7 / 4	4.6	No
444446	CHEMBL3314217	C63H83N17O11	1254.46	13 / 17	2.5	No
71110	US8592379, 37	C11H23NO2	201.31	3 / 2	0.9	Yes
71111	US8592379, 35	C11H23NO2	201.31	3 / 2	0.9	Yes
71876	CHEMBL389262	C40H59N11O6	789.983	8 / 10	0.7	No
444601	CHEMBL3314209	C60H81N17O11	1216.42	14 / 16	1.3	No
78730	CID 44419652	C74H106N22O19	1607.8	21 / 23	-5.3	No
444923	CHEMBL3422413	C69H93N17O16	1416.61	17 / 20	-0.1	No
81779	CHEMBL223390	C42H54N10O7	810.957	8 / 9	2.2	No
559877	CHEMBL1165432	C29H26FN5O4	527.556	8 / 4	4.2	No
559897	CHEMBL1164939	C27H23N5O3S	497.573	7 / 4	3.8	Yes
548939	CHEMBL3964403	C63H82N16O13	1271.45	14 / 16	0.8	No
560074	CHEMBL1164673	C24H18N4O2S	426.494	6 / 3	4.1	Yes
91857	CHEMBL268579	C40H51N11O6	781.919	8 / 9	1.5	No
92004	CHEMBL2152063	C63H83N17O14	1302.46	16 / 18	-1.8	No
92354	CHEMBL375432	C78H107N19O18	1598.83	20 / 20	-1.9	No
548990	CHEMBL3976038	C59H84N16O13	1225.42	14 / 17	0.8	No
92801	CHEMBL388585	C41H51ClN10O6	815.373	7 / 9	2.9	No
93156	CHEMBL415004	C42H54N10O7	810.957	8 / 10	1.4	No
93161	Peptide analogue, 24a	C42H54FN9O6	799.949	8 / 9	3.0	No
93162	Peptide analogue, 25b	C42H54FN9O6	799.949	8 / 9	3.0	No
93163	Peptide analogue, 24b	C42H54FN9O6	799.949	8 / 9	3.0	No
93164	Peptide analogue, 25a	C42H54FN9O6	799.949	8 / 9	3.0	No
445503	CHEMBL3314221	C61H80N16O11	1213.41	13 / 17	2.4	No
445522	CHEMBL3314220	C60H78N16O11	1199.39	13 / 17	2.0	No
560321	CHEMBL1163739	C27H23N5O4	481.512	7 / 4	3.7	Yes
99859	BDBM50392498	C63H82N18O15	1331.46	17 / 19	-3.1	No
517846	CHEMBL3926886	C11H21NO	183.295	2 / 1	1.8	Yes
445634	CHEMBL3314218	C57H76N16O11	1161.34	14 / 16	0.8	No
100981	CHEMBL2152062	C62H81N17O14	1288.44	16 / 18	-2.4	No
445747	CHEMBL3314219	C58H78N16O12	1191.36	15 / 17	0.2	No
560506	CHEMBL1171483	C28H25ClFN5O4	549.987	8 / 4	N/A	No
103483	CHEMBL2151646	C63H84N18O14	1317.48	16 / 19	-1.4	No
103485	CHEMBL2151654	C63H84N18O14	1317.48	16 / 19	-1.4	No
103487	CHEMBL3085804	C63H84N18O14	1317.48	16 / 19	-1.4	No
103490	CHEMBL3087925	C63H84N18O14	1317.48	16 / 19	-1.4	No
103611	CHEMBL2152052	C63H83N15O14	1274.45	16 / 17	-1.1	No
107726	CHEMBL387648	C49H61N11O6	900.098	8 / 10	3.1	No
109663	CHEMBL3645500	C11H23NO	185.311	2 / 1	1.9	Yes
560822	CHEMBL1170894	C29H26FN5O4	527.556	8 / 3	4.3	No
116180	CHEMBL2152067	C62H80N16O15	1289.42	17 / 18	-2.6	No
560927	CHEMBL1172940	C28H24FN5O3	497.53	8 / 2	4.7	Yes
122482	CHEMBL2152054	C62H81N15O14	1260.42	16 / 17	-1.4	No
122634	CHEMBL226566	C41H52N10O7	796.93	8 / 10	1.9	No
123519	CHEMBL2152066	C60H77N15O14	1232.37	16 / 17	-2.1	No
446596	CHEMBL3422406	C63H83N17O15	1318.46	17 / 19	-2.4	No
561239	CHEMBL1171977	C27H22FN5O4	499.502	8 / 3	4.0	Yes
561254	CHEMBL1163888	C27H23N5O3S	497.573	7 / 4	4.3	Yes
128470	CID 44419665	C69H106N24O18	1559.76	21 / 25	-6.5	No

zhanglab

zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417