Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

You can:

Check the GPCR table for details.
Go to the ligand list to see ligands that interacts with this GPCR.
Go to the individual ligand page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

GPCR

Name	Neurotensin receptor type 1
Species	Mus musculus (Mouse)
Gene	Ntsr1
Synonym	NTS1 receptor NTRH NTR1 NTR NT-R-1 NT-1R neurotensin receptor type 1 neurotensin receptor 1 (high affinity) Levocabastin-insensitive neurotensin receptor NTSR1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	424
Amino acid sequence	MHLNSSVQQGAPSEPGAQPFPHPQFGLETMLLALSLSNGSGNSSESILEPNSNLDVNTDIYSKVLVTAVYLALFVVGTVGNSVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGLQNRSADGQHPGGLVCTPTVDTATVKVVIQVNTFMSFLFPMLIISILNTVIANKLTVMVHQAAEQGRGVCTVGTHNSLEHSTFNMSIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVFLSTLACLCPGWRRRRKKRPTFSRKPNSMSSNHAFSTSATRETLY
UniProt	O88319
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3570
IUPHAR	309
DrugBank	N/A

Known ligands

You can:

Click GLASS IDs to check the association information.
Click ligand names to check details of the ligands.
Download a TSV version of all interaction information.
Download a SDF structure collection of all known ligands.

GLASS ID	Molecule	Formula	Molecular weight	H-bond acceptor / donor	XlogP	Lipinski's druglikeness
20829	CHEMBL267459	C40H67N11O6	798.047	10 / 10	-0.7	No
553400	ABS-201	C40H67N9O8	802.031	10 / 9	0.4	No
37316	CHEMBL269601	C40H67N9O6	770.033	10 / 9	0.2	No
47304	CHEMBL266571	C41H67N11O7	826.057	10 / 10	-0.5	No
55082	CHEMBL38243	C23H22N2O4S	422.499	6 / 2	3.6	Yes
66206	CHEMBL342252	C38H64N12O8	817.006	11 / 11	-4.0	No
92364	CHEMBL427956	C36H57N7O6	683.895	8 / 7	0.4	No
99457	CHEMBL366912	C35H57N9O8	731.896	10 / 9	-3.0	No
101821	CHEMBL6508	C38H66N8O7	746.995	11 / 9	-0.3	No
105334	CHEMBL265671	C42H70N8O6	783.072	9 / 7	4.4	No
127891	CHEMBL412980	C75H118N20O19	1603.89	22 / 20	-3.2	No
144206	CHEMBL427604	C40H67N9O6	770.033	10 / 9	0.2	No
164830	CHEMBL367552	C38H65N13O7	816.022	10 / 11	-0.9	No
172356	CHEMBL173256	C29H54N12O7	682.828	10 / 10	-6.5	No
176867	CHEMBL6716	C38H61N11O6	767.977	8 / 9	1.4	No
197564	CHEMBL6562	C42H71N9O6	798.087	10 / 8	3.2	No
197903	CHEMBL441754	C60H98N18O16	1327.55	19 / 17	-5.2	No
203575	CHEMBL380726	C34H53N7O6	655.841	8 / 7	0.1	No
214681	CHEMBL174438	C35H58N12O8	774.925	11 / 11	-4.2	No
228498	CHEMBL405151	C55H91N17O13	1198.44	16 / 15	-4.4	No
236622	CHEMBL367873	C32H54N12O6	702.862	9 / 10	-2.3	No
253099	CHEMBL264534	C51H85N15O11	1084.33	14 / 13	-2.7	No
256345	NEUROTENSIN	C78H121N21O20	1672.95	23 / 21	-3.7	No
303521	CHEMBL413433	C69H107N19O18	1490.73	21 / 19	-4.2	No
310956	CHEMBL172473	C35H57N9O8	731.896	10 / 9	-3.0	No
318797	CHEMBL172313	C35H58N12O8	774.925	11 / 11	-5.3	No
327714	CHEMBL6505	C38H61N7O6	711.949	8 / 7	1.1	No
330998	CHEMBL1793865	C38H66N8O7	746.995	11 / 9	-0.3	No
356103	CHEMBL268600	C42H71N11O6	826.101	10 / 9	2.2	No
357209	BDBM82078	C36H58N8O9	746.907	11 / 9	-1.8	No
363621	CHEMBL425847	C36H62N12O8	790.968	11 / 12	-3.9	No
410700	CHEMBL174771	C45H73N13O10	956.16	12 / 11	0.1	No
418275	CHEMBL171907	C32H60N12O7	724.909	10 / 10	-5.2	No
437427	CHEMBL344337	C40H66N12O9	859.043	11 / 11	0.1	No

zhanglab

zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417