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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 1D
Species	Homo sapiens (Human)
Gene	HTR1D
Synonym	Serotonin 1D alpha receptor serotonin receptor 1D HTRL Htr1db 5-HT-1D 5-HT-1D-alpha 5-HT1D 5-HT1D receptor 5-HT1Dalpha 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled Gpcr14 HT1DA [ Show all ]
Disease	Acute migraine Epilepsy Migraine headaches Mood disorder Migraine Major depressive disorder Severe mood disorders [ Show all ]
Length	377
Amino acid sequence	MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
UniProt	P28221
Protein Data Bank	N/A
GPCR-HGmod model	P28221
3D structure model	This predicted structure model is from GPCR-EXP P28221.
BioLiP	N/A
Therapeutic Target Database	T11072
ChEMBL	CHEMBL1983
IUPHAR	3
DrugBank	BE0000659

Ligand

Name	naratriptan
Molecular formula	C17H25N3O2S
IUPAC name	N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide
Molecular weight	335.466
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	2.0
Synonyms	AX8017803 CHEMBL1278 FC0032 N-methyl-2-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)ethane-1-sulfonamide Naramig (TN) NCGC00181786-04 AJ-08192 BDBM50073682 D08255 HY-B0197 N-methyl-2-[3-(1-methyl-4-piperidyl)-1H-indol-5-yl]ethanesulfonamide Naratriptan [INN:BAN] SC-00604 AB01565792_02 Amerge, Naramig,Naratriptan AN-11431 CHEBI:7478 DB00952 LS-83062 N-Methyl-3-(1-methyl-4 -piperidinyl)-1H-indole-5-ethansulphonamide NCGC00181786-01 ZINC4076 2-[3-(1-Methyl-piperidin-4-yl)-1H-indol-5-yl]-ethanesulfonic acid methylamide AC-5013 BC201774 Colatan FT-0656760 N-Methyl-2-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)ethanesulfonamide PubChem2191 AKOS015895854 Amerge;Naramig BIDD:GT0312 D0T3KI InChI=1/C17H25N3O2S/c1-18-23(21,22)10-7-13-3-4-17-15(11-13)16(12-19-17)14-5-8-20(2)9-6-14/h3-4,11-12,14,18-19H,5-10H2,1-2H N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethane-1-sulfonamide naratriptan; SCHEMBL68753 121679-13-8 AB2000122 API0005359 DTXSID7023354 N-methyl-2-(3-(1-methylpiperiden-4-yl)indole-5-yl)ethanesulfonamide N-Methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulphonamide NCGC00181786-03 2578AH AC1L1I6A BCP9000978 CS-2131 GTPL45 N-methyl-2-[3-(1-methyl-4-piperidyl)-1H-indol-5-yl]-ethanesulfonamide Naratriptan (INN) QX3KXL1ZA2 A25336 Amerge (TN) AMKVXSZCKVJAGH-UHFFFAOYSA-N C07792 L000432 N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide naratriptanum UNII-QX3KXL1ZA2 1H-Indole-5-ethanesulfonamide, N-methyl-3-(1-methyl-4-piperidinyl)- ABP000374 [ Show all ]
Inchi Key	AMKVXSZCKVJAGH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H25N3O2S/c1-18-23(21,22)10-7-13-3-4-17-15(11-13)16(12-19-17)14-5-8-20(2)9-6-14/h3-4,11-12,14,18-19H,5-10H2,1-2H3
PubChem CID	4440
ChEMBL	CHEMBL1278
IUPHAR	45
BindingDB	50073682
DrugBank	DB00952
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
EC50	1.6 nM	PMID9986723	BindingDB,ChEMBL
Emax	100.0 %	PMID9986723	ChEMBL
Ki	1.0 - 3.98108 nM	PMID10193663, PMID9303569, PMID7780656	IUPHAR
Ki	1.5 nM	PMID9303569	PDSP,BindingDB
Ki	2.3 nM	PMID9986723	BindingDB,ChEMBL

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