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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Platelet-activating factor receptor
Species	Mus musculus (Mouse)
Gene	Ptafr
Synonym	AGEPC receptor PAF receptor PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	341
Amino acid sequence	MEHNGSFRVDSEFRYTLFPIVYSVIFILGVVANGYVLWVFANLYPSKKLNEIKIFMVNLTMADLLFLITLPLWIVYYYNEGDWILPNFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGISLSLIIWVSIVATASYFLATDSTNLVPNKDGSGNITRCFEHYEPYSVPILVVHVFIAFCFFLVFFLIFYCNLVIIHTLLTQPMRQQRKAGVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVIVPANQTPIVSLKN
UniProt	Q62035
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3993
IUPHAR	334
DrugBank	N/A

Ligand

Name	CHEMBL320676
Molecular formula	C24H27N5O
IUPAC name	2-(2-methylpyridin-3-yl)-2-[4-[3-phenyl-3-(prop-2-ynylamino)propanoyl]piperazin-1-yl]acetonitrile
Molecular weight	401.514
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	1.5
Synonyms	BDBM50045957 SCHEMBL9575029 (2-Methyl-pyridin-3-yl)-[4-(3-phenyl-3-prop-2-ynylamino-propionyl)-piperazin-1-yl]-acetonitrile [4-[3-Phenyl-1-oxo-3-[(2-propynyl)amino]propyl]piperazin-1-yl](2-methyl-3-pyridyl)acetonitrile
Inchi Key	FTNUHMUEBLWYBC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H27N5O/c1-3-11-27-22(20-8-5-4-6-9-20)17-24(30)29-15-13-28(14-16-29)23(18-25)21-10-7-12-26-19(21)2/h1,4-10,12,22-23,27H,11,13-17H2,2H3
PubChem CID	10318877
ChEMBL	CHEMBL320676
IUPHAR	N/A
BindingDB	50045957
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
ID50	3.0 mg.kg-1	PMID8411016	ChEMBL

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