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GPCR

NameNeuropeptide Y receptor type 2
SpeciesHomo sapiens (Human)
GeneNPY2R
SynonymNPY2-R
NPY-Y2 receptor
neuropeptide Y receptor type 2
Y2 receptor
DiseaseDiabetes
Metabolic disorders
Obesity
Length381
Amino acid sequenceMGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
UniProtP49146
Protein Data BankN/A
GPCR-HGmod modelP49146
3D structure modelThis predicted structure model is from GPCR-EXP P49146.
BioLiPN/A
Therapeutic Target DatabaseT10670
ChEMBLCHEMBL4018
IUPHAR306
DrugBankBE0002419

Ligand

NameCHEMBL1081469
Molecular formulaC18H18N4S2
IUPAC nameN-[2-[4-(4,5-dihydro-1,3-thiazol-2-ylamino)phenyl]ethyl]-1,3-benzothiazol-2-amine
Molecular weight354.49
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP4.5
SynonymsSCHEMBL14000703
BDBM50312007
N-(4-(4,5-dihydrothiazol-2-ylamino)phenethyl)benzo[d]thiazol-2-amine
Inchi KeyFTGKJTDOICYFTN-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H18N4S2/c1-2-4-16-15(3-1)22-18(24-16)19-10-9-13-5-7-14(8-6-13)21-17-20-11-12-23-17/h1-8H,9-12H2,(H,19,22)(H,20,21)
PubChem CID46880224
ChEMBLCHEMBL1081469
IUPHARN/A
BindingDB50312007
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMPMID19864135BindingDB,ChEMBL

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