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GPCR

Name	2-oxoglutarate receptor 1
Species	Homo sapiens (Human)
Gene	OXGR1
Synonym	Alpha-ketoglutarate receptor 1 P2Y15 P2Y-like nucleotide receptor P2Y-like GPCR P2Y purinoceptor 15 P2RY15 oxoglutarate receptor GPR99 G-protein coupled receptor 99 G-protein coupled receptor 80 G protein-coupled receptor 99 G protein-coupled receptor 80 2-oxoglutarate receptor 1 GPR80 [ Show all ]
Disease	N/A
Length	337
Amino acid sequence	MNEPLDYLANASDFPDYAAAFGNCTDENIPLKMHYLPVIYGIIFLVGFPGNAVVISTYIFKMRPWKSSTIIMLNLACTDLLYLTSLPFLIHYYASGENWIFGDFMCKFIRFSFHFNLYSSILFLTCFSIFRYCVIIHPMSCFSIHKTRCAVVACAVVWIISLVAVIPMTFLITSTNRTNRSACLDLTSSDELNTIKWYNLILTATTFCLPLVIVTLCYTTIIHTLTHGLQTDSCLKQKARRLTILLLLAFYVCFLPFHILRVIRIESRLLSISCSIENQIHEAYIVSRPLAALNTFGNLLLYVVVSDNFQQAVCSTVRCKVSGNLEQAKKISYSNNP
UniProt	Q96P68
Protein Data Bank	N/A
GPCR-HGmod model	Q96P68
3D structure model	This predicted structure model is from GPCR-EXP Q96P68.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2150840
IUPHAR	162
DrugBank	N/A

Ligand

Name	2-ketoglutaric acid
Molecular formula	C5H6O5
IUPAC name	2-oxopentanedioic acid
Molecular weight	146.098
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	-0.9
Synonyms	Pentanedioic acid, 2-oxo-, sodium salt (1:?) ST45138045 ZINC1532519 Glutaric acid, .alpha.-keto- 2OG InChI=1/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10 4oct LS-183918 AB00640269-03 NCGC00013225-03 AKG NCI60_001411 alpha-Ketoglutaric acid, >=98.5% (NaOH, titration) Oxoglutarate AM20090486 bmse000064 11044-EP2316825A1 CHEBI:30915 2-ketoglutarate DSSTox_CID_13179 2-oxoglutarate RTR-032306 Tox21_200918 2-oxopentanedionate Glutaric acid, alpha keto 34410-46-3 KB-68907 86248-59-1 (calcium[2:1]salt) MolPort-001-661-996 AC1Q5RHM NCGC00013225-06 alpha ketoglutaric acid NSC 17391 alpha-Ketoglutaricum acidum Pentanedioic acid, 2-oxo- (9CI) AS-12579 11044-EP2269610A2 BR-41634 11044-EP2316828A1 CTK1C2721 2-Ketoglutaricacid DTXSID5033179 SCHEMBL7400 UNII-8ID597Z82X 22202-68-2 (mono-hydrochloride salt) I04-0237 3ouj KS-00000CEL 997-43-3 (mono-potassium salt) NCGC00013225-01 AJ-26772 NCGC00258472-01 alpha-ketoglutaric acid Oxoglurate alpha-Oxopentanedioic acid BDBM50303766 11044-EP2316457A1 CAS-328-50-7 17091-15-5 DB02926 2-Oxo-Glutaric Acid F2191-0182 Pentanedioic acid, oxo- STK002174 Glutaric acid, 2-oxo- 305-72-6 (di-hydrochloride salt) Jsp006044 4qkd MCULE-5148157449 AB1011137 NCGC00013225-04 AKOS000120908 NCIStruc1_001710 alpha-Ketoglutaric acid, >=99.0% (T) Oxoglutaric acid AN-23401 .alpha.-Ketoglutaric acid bmse000801 11044-EP2316826A1 CHEMBL1686 DSSTox_GSID_33179 2-oxoglutaric acid SBB056419 TR-032306 2-OXYGLUTARIC ACID GTPL3636 keto glutaric acid 8ID597Z82X MP-2190 ACMC-1BMR3 NCGC00090946-01 alpha-keto-Glutaric acid NSC-17391 alpha-oxo-glutaric acid BBL010614 11044-EP2277848A1 C00026 15118487-024F-412C-9995-24E8E6CA72EF D09KQZ 2-Oxo-1,5-pentanedioate EBD44199 Pentanedioic acid, 2-oxo-, sodium salt ST24032496 Z57127547 FT-0612734 27175-99-1 I14-33772 4nro KSC222O2D a-ketoglutaric acid NCGC00013225-02 AK-41634 NCI17391 alpha-Ketoglutaric acid alpha Oxoglurate [INN] Alphaketoglutaric acid Bis(L-arginin)-2-oxoglutarat 11044-EP2316458A1 CCG-37641 17091-15-5 (hydrochloride salt) DB03806 2-oxo-pentanedioic acid RP21033 Tox21_110016 Glutaric acid, 2-oxo- (8CI) 328-50-7 K0005 4usi MFCD00004165 AC1L18DA NCGC00013225-05 alpha Ketoglutarate NCIStruc2_000215 alpha-Ketoglutaric acid, BioReagent, suitable for cell culture, suitable for insect cell culture Pentanedioic acid, 2-oxo- ANW-27470 .alpha.-Oxoglutaric acid bmse000937 11044-EP2316827A1 CS-W014352 2-Ketoglutaric acid, 98% DSSTox_RID_79054 2-Oxopentanedioic acid SC-16448 TRA0076832 22202-68-2 HY-W013636 378-50-7 KPGXRSRHYNQIFN-UHFFFAOYSA-N 997-43-3 NCGC00013225 AI3-26938 NCGC00090946-02 alpha-ketoglutarate NSC17391 alpha-Oxoglutaric acid BC206209 11044-EP2289510A1 C5H6O5 15303-07-8 (di-ammonium salt) DB-048280 2-Oxo-1,5-pentanedioic acid EINECS 206-330-3 [ Show all ]
Inchi Key	KPGXRSRHYNQIFN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
PubChem CID	51
ChEMBL	N/A
IUPHAR	3636
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	32000.0 - 69000.0 nM	PMID15141213, PMID23396314	IUPHAR

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