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GPCR

Name	Beta-3 adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRB3
Synonym	ADRB Adrb-3 adrenergic receptor atypical beta-adrenoceptor beta 3-AR Beta-3 adrenoceptor Beta-3 adrenoreceptor beta3-adrenergic receptor beta3-adrenoceptor [ Show all ]
Disease	Urinary incontinence Diabetes Glaucoma Hypertension Irritable bowel syndrome Major depressive disorder; Obesity; Type 2 diabetes Major depressive disorder; Severe mood disorders Obesity Gastrointestinal disease Obesity; Type 2 diabetes Asthma; Chronic obstructive pulmonary disease Asthma Angina pectoris Overactive bladder disorder Type 2 diabetes [ Show all ]
Length	408
Amino acid sequence	MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
UniProt	P13945
Protein Data Bank	N/A
GPCR-HGmod model	P13945
3D structure model	This predicted structure model is from GPCR-EXP P13945.
BioLiP	N/A
Therapeutic Target Database	T51408
ChEMBL	CHEMBL246
IUPHAR	30
DrugBank	BE0001012, BE0004872

Ligand

Name	Carazolol
Molecular formula	C18H22N2O2
IUPAC name	1-(9H-carbazol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol
Molecular weight	298.386
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	3.6
Synonyms	1-((9H-Carbazol-4-yl)oxy)-3-(isopropylamino)propan-2-ol 1-(9H-Carbazol-4-yloxy)-3-isopropylamino-propan-2-ol(carazolol) API0001839 Carazolol (INN) D0A9ED MolPort-003-845-579 1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-((1-methylethyl)amino)- 75C298 BM-51052 Carazololum Conducton (TN) GTPL569 SCHEMBL77902 (isopropylamino)propan-2-ol 1-(9H-carbazol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol 4-(2-Hydroxy-3-isopropylamino-propoxy)-carbazole AKOS027320502 C-18674 CCRIS 1047 CTK4J5240 LS-121876 Suacron [veterinary] (TN) 1-(4-Carbazolyloxy)-3-isopropylamino-2-propanol 1-(9H-Carbazol-4-yloxy-3-((1-methylethyl)amino)-2-propanol) BDBM50027663 Carazolol [INN:BAN] CHEMBL324665 EINECS 260-945-1 SC-43892 1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol # 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-[(1-methylethyl)amino]- AC1L2GQ1 BQXQGZPYHWWCEB-UHFFFAOYSA-N Carazololum [INN-Latin] Conducton hydrochloride KS-000012CA SMR002529709 1-(9H-Carbazol-4-yloxy)-3-isopropylamino-propan-2-ol 4-(2-Hydroxy-3-isopropylamino-propoxy)carbazole AN-16968 CHEBI:135261 D07608 MLS006010892 VA10483 1-(9H-carbazol-4-yloxy)-3- 1-(Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol 57775-29-8 BM 51052 Carazolol, analytical standard Conducton FT-0601602 SCHEMBL77901 1-(9H-carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol 2-Propanol,1-(9H-carbazol-4-yloxy)-3-[(1-methylethyl)amino]- AC1Q77JM BRN 3620576 CC-25380 corazolol L000159 Suacron [ Show all ]
Inchi Key	BQXQGZPYHWWCEB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H22N2O2/c1-12(2)19-10-13(21)11-22-17-9-5-8-16-18(17)14-6-3-4-7-15(14)20-16/h3-9,12-13,19-21H,10-11H2,1-2H3
PubChem CID	71739
ChEMBL	CHEMBL324665
IUPHAR	569
BindingDB	50027663
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1.99 nM	PMID8719421	IUPHAR

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