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GPCR

Name	Alpha-2C adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2C
Synonym	alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I adrenergic receptor alpha-2 adrenergic receptor subtype C4 alpha2C-adrenoceptor alpha-2C adrenergic receptor Alpha-2C adrenoceptor alpha-2C adrenoreceptor Alpha-2CAR [ Show all ]
Disease	Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease Asthma Erythema Contusion Depression Hypotension Male sexual disorders Neurological disease Obesity Ocular disease Allergic rhinitis Alcohol use disorders Ocular hypertension Poison intoxication Peptic ulcer Pain [ Show all ]
Length	462
Amino acid sequence	MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P18825
Protein Data Bank	N/A
GPCR-HGmod model	P18825
3D structure model	This predicted structure model is from GPCR-EXP P18825.
BioLiP	N/A
Therapeutic Target Database	T01777
ChEMBL	CHEMBL1916
IUPHAR	27
DrugBank	BE0004864, BE0000342, BE0004888

Ligand

Name	Pizotifen
Molecular formula	C19H21NS
IUPAC name	1-methyl-4-(6-thiatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaen-2-ylidene)piperidine
Molecular weight	295.444
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.8
Synonyms	AB00514749_12 Pizotyline; 4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine BBL009911 Sanomigran BRD-K75958195-001-01-7 UNII-0BY8440V3N CHEBI:50212 DB06153 FT-0637249 LS-115012 NCGC00163169-05 15574-96-6 Piperidine,4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methyl- 4-Oxo-9,10-dihydro-4H-benzo(4,5) cyclohepto(1,2,b)thiophene Pizotifeno AC1Q7FY1 Sandomigram BC203862 SCHEMBL44122 BRN 0753534 CS-1870 DSSTox_RID_77051 H903 MLS006011927 P2344 4-(9,10-Dihydro-4H-benzo(4,5)cyclohepta(1,2-b)thien-4-ylidene)-1-methylpiperidine Pizotifen (INN) Pizotifenum [INN-Latin] Pizotyline maleate (Salt/Mix) API0003882 Sandomygran Biomol-NT_000102 Tox21_112024 CAS-15574-96-6 D06XZR FIADGNVRKBPQEU-UHFFFAOYSA-N L000722 NCGC00163169-02 1-methyl-4-{6-thiatricyclo[8.4.0.0?,?]tetradeca-1(14),3(7),4,10,12-pentaen-2-ylidene}piperidine Piperidine, 4-(9,10-dihydro-4H-benzo(4,5)cyclohepta(1,2-b)thien-4-ylidene)-1-methyl- 4-OXO-9,10-DIHYDRO-4H-BENZO(4,5) CYCLOHEPTO(1,2,B) Pizotifene AB00514749 AC-11996 Pizotylline BC 105 SBI-0206788.P001 BRD-K75958195-037-03-7 W-108016 DSSTox_CID_3490 FT-0655575 MCULE-5738749931 NSC_27400 4-(1-Methyl-4-piperidylidene)-9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophene Pizotifan 4-[9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene]-1-methylpiperidine Pizotifeno [INN-Spanish] PIZOTYLINE AKOS005612964 Sandomigran BCP14794 SMR004703517 C-18523 CTK8G2451 DTXSID6023490 HY-B0115 MolPort-002-654-036 PDSP1_001602 4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine Pizotifen [INN] Pizotyline [USAN] AS-13328 Sanmigran BPBio1_001391 Tox21_112024_1 CAS_15574-96-6 FT-0082645 Litec NCGC00163169-03 1-methyl-4-{6-thiatricyclo[8.4.0.0^{3,7}]tetradeca-1(14),3(7),4,10,12-pentaen-2-ylidene}piperidine Piperidine, 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methyl- 4-OXO-9,10-DIHYDRO-4H-BENZO(4,5) CYCLOHEPTO(1,2,B) THIOPHENE Pizotifene [INN-French] AB00514749_11 AC1L1D4Y Polomigran BC-105 SC-46107 BRD-K75958195-037-04-5 ZINC1968 CHEMBL294951 DSSTox_GSID_23490 GTPL93 MFCD00864192 Oprea1_684518 4-(9,10-dihydro-1-thiabenzo[f]azulen-4-ylidene)-1-methylpiperidine 574P966 Pizotifenum Pizotyline (USAN) AN-920 Sandomigran (TN) BDBM82088 STK801341 C19H21NS D05523 EINECS 239-632-9 KS-000017QX NCGC00163169-01 0BY8440V3N PDSP2_001586 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-methylpiperidine Pizotifen, >=98% (HPLC) AB0013346 [ Show all ]
Inchi Key	FIADGNVRKBPQEU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H21NS/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18/h2-5,10,13H,6-9,11-12H2,1H3
PubChem CID	27400
ChEMBL	CHEMBL294951
IUPHAR	93
BindingDB	82088
DrugBank	DB06153
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank

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