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GPCR

Name5-hydroxytryptamine receptor 2A
SpeciesMus musculus (Mouse)
GeneHtr2a
Synonymserotonin 5HT-2 receptor
5Ht-2
'D' receptor
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
5-HT2A receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length471
Amino acid sequenceMEILCEDNISLSSIPNSLMQLGDDSRLYPNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLSSFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPTLAYKSSQLQVGQKKNSQEDAEPTANDCSMVTLGNQHSEEMCTDNIETVNEKVSCV
UniProtP35363
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5377
IUPHARN/A
DrugBankN/A

Ligand

Name1-[(2-chloro-1,3-thiazol-5-yl)methyl]-4-phenylpiperazine
Molecular formulaC14H16ClN3S
IUPAC name2-chloro-5-[(4-phenylpiperazin-1-yl)methyl]-1,3-thiazole
Molecular weight293.813
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP3.4
Synonyms9P-927
KS-00003GFA
Bionet2_000634
MolPort-002-883-444
2-chloro-5-[(4-phenylpiperazin-1-yl)methyl]-1,3-thiazole
[ Show all ]
Inchi KeyCZPHEYMHFHOUKP-UHFFFAOYSA-N
Inchi IDInChI=1S/C14H16ClN3S/c15-14-16-10-13(19-14)11-17-6-8-18(9-7-17)12-4-2-1-3-5-12/h1-5,10H,6-9,11H2
PubChem CID1489112
ChEMBLCHEMBL1487540
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50815.08 nMPubChem BioAssay data setChEMBL

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