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GPCR

NameProlactin-releasing peptide receptor
SpeciesHomo sapiens (Human)
GenePRLHR
SynonymPrRP receptor
hGR3
GPR10
G-protein coupled receptor 10
G protein-coupled receptor 10
[ Show all ]
DiseaseN/A
Length370
Amino acid sequenceMASSTTRGPRVSDLFSGLPPAVTTPANQSAEASAGNGSVAGADAPAVTPFQSLQLVHQLKGLIVLLYSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCTACVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRISLRLSAYAVLAIWALSAVLALPAAVHTYHVELKPHDVRLCEEFWGSQERQRQLYAWGLLLVTYLLPLLVILLSYVRVSVKLRNRVVPGCVTQSQADWDRARRRRTFCLLVVIVVVFAVCWLPLHVFNLLRDLDPHAIDPYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKLLVAWPRKIAPHGQNMTVSVVI
UniProtP49683
Protein Data BankN/A
GPCR-HGmod modelP49683
3D structure modelThis predicted structure model is from GPCR-EXP P49683.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1681611
IUPHAR337
DrugBankN/A

Ligand

NameSCHEMBL437445
Molecular formulaC25H29FN4O3
IUPAC name4-[2-[(2S)-2-cyclohexylpropyl]-3-methoxy-4-oxo-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carbonyl]-3-fluorobenzonitrile
Molecular weight452.53
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP3.8
SynonymsUS9206173, 2472
CHEMBL3910912
BDBM195710
Inchi KeyBQRQONDDIGZZHP-INIZCTEOSA-N
Inchi IDInChI=1S/C25H29FN4O3/c1-16(18-6-4-3-5-7-18)12-23-28-22-10-11-29(15-20(22)25(32)30(23)33-2)24(31)19-9-8-17(14-27)13-21(19)26/h8-9,13,16,18H,3-7,10-12,15H2,1-2H3/t16-/m0/s1
PubChem CID66686121
ChEMBLCHEMBL3910912
IUPHARN/A
BindingDB195710
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki61.0 nM, NoneBindingDB,ChEMBL

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