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GPCR

NameC-C chemokine receptor type 10
SpeciesHomo sapiens (Human)
GeneCCR10
SynonymCCR-10
CCR10
CC-CKR-10
G-protein coupled receptor 2
GPR-2
[ Show all ]
DiseaseInflammatory disease
Length362
Amino acid sequenceMGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFSQDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSWDN
UniProtP46092
Protein Data BankN/A
GPCR-HGmod modelP46092
3D structure modelThis predicted structure model is from GPCR-EXP P46092.
BioLiPN/A
Therapeutic Target DatabaseT71054
ChEMBLCHEMBL2321628
IUPHAR67
DrugBankN/A

Ligand

NameCHEMBL3727436
Molecular formulaC28H29ClFN7O4S
IUPAC name1-[7-(2-chloro-5-methylanilino)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidin-3-yl]sulfonyl-3-ethylurea
Molecular weight614.093
Hydrogen bond acceptor8
Hydrogen bond donor3
XlogP4.5
Synonyms7-(2-Chloro-5-methylanilino)-N-(ethylcarbamoyl)-6-[[4-(4-fluorophenyl)piperidino]carbonyl]pyrazolo[1,5-a]pyrimidine-3-sulfonamide
SCHEMBL14471851
Inchi KeySLPKOJIFSYDSPG-UHFFFAOYSA-N
Inchi IDInChI=1S/C28H29ClFN7O4S/c1-3-31-28(39)35-42(40,41)24-16-33-37-25(34-23-14-17(2)4-9-22(23)29)21(15-32-26(24)37)27(38)36-12-10-19(11-13-36)18-5-7-20(30)8-6-18/h4-9,14-16,19,34H,3,10-13H2,1-2H3,(H2,31,35,39)
PubChem CID71178991
ChEMBLCHEMBL3727436
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition<100.0 %NoneChEMBL

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