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GPCR

NameC-C chemokine receptor type 10
SpeciesHomo sapiens (Human)
GeneCCR10
SynonymCCR-10
CCR10
CC-CKR-10
G-protein coupled receptor 2
GPR-2
[ Show all ]
DiseaseInflammatory disease
Length362
Amino acid sequenceMGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFSQDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSWDN
UniProtP46092
Protein Data BankN/A
GPCR-HGmod modelP46092
3D structure modelThis predicted structure model is from GPCR-EXP P46092.
BioLiPN/A
Therapeutic Target DatabaseT71054
ChEMBLCHEMBL2321628
IUPHAR67
DrugBankN/A

Ligand

NameCHEMBL3733183
Molecular formulaC26H21Cl2FN8O3S2
IUPAC name7-(2,5-dichloroanilino)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]-N-(1,3,4-thiadiazol-2-yl)pyrazolo[1,5-a]pyrimidine-3-sulfonamide
Molecular weight647.525
Hydrogen bond acceptor11
Hydrogen bond donor2
XlogP5.1
SynonymsSCHEMBL15915652
Inchi KeyOSXXXLRTSIMZRN-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H21Cl2FN8O3S2/c27-17-3-6-20(28)21(11-17)33-23-19(25(38)36-9-7-16(8-10-36)15-1-4-18(29)5-2-15)12-30-24-22(13-32-37(23)24)42(39,40)35-26-34-31-14-41-26/h1-6,11-14,16,33H,7-10H2,(H,34,35)
PubChem CID90313007
ChEMBLCHEMBL3733183
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition<100.0 %NoneChEMBL

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