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GPCR

NameProlactin-releasing peptide receptor
SpeciesHomo sapiens (Human)
GenePRLHR
SynonymPrRP receptor
hGR3
GPR10
G-protein coupled receptor 10
G protein-coupled receptor 10
[ Show all ]
DiseaseN/A
Length370
Amino acid sequenceMASSTTRGPRVSDLFSGLPPAVTTPANQSAEASAGNGSVAGADAPAVTPFQSLQLVHQLKGLIVLLYSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCTACVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRISLRLSAYAVLAIWALSAVLALPAAVHTYHVELKPHDVRLCEEFWGSQERQRQLYAWGLLLVTYLLPLLVILLSYVRVSVKLRNRVVPGCVTQSQADWDRARRRRTFCLLVVIVVVFAVCWLPLHVFNLLRDLDPHAIDPYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKLLVAWPRKIAPHGQNMTVSVVI
UniProtP49683
Protein Data BankN/A
GPCR-HGmod modelP49683
3D structure modelThis predicted structure model is from GPCR-EXP P49683.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1681611
IUPHAR337
DrugBankN/A

Ligand

NameSCHEMBL447348
Molecular formulaC25H24ClF6N5O2
IUPAC name3-(dimethylamino)-6-(2,4,6-trifluorobenzoyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one;hydrochloride
Molecular weight575.94
Hydrogen bond acceptor10
Hydrogen bond donor2
XlogPNone
SynonymsCHEMBL3728492
Inchi KeyKWMQFNWGZLXEOY-ZOWNYOTGSA-N
Inchi IDInChI=1S/C25H23F6N5O2.ClH/c1-13(14-4-6-15(7-5-14)25(29,30)31)32-24-33-20-8-9-35(12-17(20)22(37)36(24)34(2)3)23(38)21-18(27)10-16(26)11-19(21)28;/h4-7,10-11,13H,8-9,12H2,1-3H3,(H,32,33);1H/t13-;/m0./s1
PubChem CID87108834
ChEMBLCHEMBL3728492
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
IC50216.0 nMNoneChEMBL
Ki6.0 nMNoneChEMBL

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