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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Prolactin-releasing peptide receptor
Species	Homo sapiens (Human)
Gene	PRLHR
Synonym	PrRP receptor hGR3 GPR10 G-protein coupled receptor 10 G protein-coupled receptor 10 PrRPR [ Show all ]
Disease	N/A
Length	370
Amino acid sequence	MASSTTRGPRVSDLFSGLPPAVTTPANQSAEASAGNGSVAGADAPAVTPFQSLQLVHQLKGLIVLLYSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCTACVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRISLRLSAYAVLAIWALSAVLALPAAVHTYHVELKPHDVRLCEEFWGSQERQRQLYAWGLLLVTYLLPLLVILLSYVRVSVKLRNRVVPGCVTQSQADWDRARRRRTFCLLVVIVVVFAVCWLPLHVFNLLRDLDPHAIDPYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKLLVAWPRKIAPHGQNMTVSVVI
UniProt	P49683
Protein Data Bank	N/A
GPCR-HGmod model	P49683
3D structure model	This predicted structure model is from GPCR-EXP P49683.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1681611
IUPHAR	337
DrugBank	N/A

Ligand

Name	SCHEMBL435913
Molecular formula	C28H27F3N4O3
IUPAC name	3-but-2-ynyl-6-(4-methoxybenzoyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one
Molecular weight	524.544
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.7
Synonyms	US9206173, 2448 CHEMBL3732511 BDBM195686
Inchi Key	GKXULTSPVNRIHV-SFHVURJKSA-N
Inchi ID	InChI=1S/C28H27F3N4O3/c1-4-5-15-35-26(37)23-17-34(25(36)20-8-12-22(38-3)13-9-20)16-14-24(23)33-27(35)32-18(2)19-6-10-21(11-7-19)28(29,30)31/h6-13,18H,14-17H2,1-3H3,(H,32,33)/t18-/m0/s1
PubChem CID	66685775
ChEMBL	CHEMBL3732511
IUPHAR	N/A
BindingDB	195686
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	23.0 nM	, None	BindingDB,ChEMBL

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