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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prolactin-releasing peptide receptor
Species	Homo sapiens (Human)
Gene	PRLHR
Synonym	PrRP receptor hGR3 GPR10 G-protein coupled receptor 10 G protein-coupled receptor 10 PrRPR [ Show all ]
Disease	N/A
Length	370
Amino acid sequence	MASSTTRGPRVSDLFSGLPPAVTTPANQSAEASAGNGSVAGADAPAVTPFQSLQLVHQLKGLIVLLYSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCTACVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRISLRLSAYAVLAIWALSAVLALPAAVHTYHVELKPHDVRLCEEFWGSQERQRQLYAWGLLLVTYLLPLLVILLSYVRVSVKLRNRVVPGCVTQSQADWDRARRRRTFCLLVVIVVVFAVCWLPLHVFNLLRDLDPHAIDPYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKLLVAWPRKIAPHGQNMTVSVVI
UniProt	P49683
Protein Data Bank	N/A
GPCR-HGmod model	P49683
3D structure model	This predicted structure model is from GPCR-EXP P49683.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1681611
IUPHAR	337
DrugBank	N/A

Ligand

Name	CHEMBL3916965
Molecular formula	C27H26F3N5O2
IUPAC name	3-but-3-ynyl-6-(4-methylbenzoyl)-2-[2-methyl-2-[4-(trifluoromethyl)phenyl]hydrazinyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one
Molecular weight	509.533
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	4.1
Synonyms	BDBM195681 US9206173, 2443
Inchi Key	GXRZGJQHZBJQMB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H26F3N5O2/c1-4-5-15-35-25(37)22-17-34(24(36)19-8-6-18(2)7-9-19)16-14-23(22)31-26(35)32-33(3)21-12-10-20(11-13-21)27(28,29)30/h1,6-13H,5,14-17H2,2-3H3,(H,31,32)
PubChem CID	122197730
ChEMBL	CHEMBL3916965
IUPHAR	N/A
BindingDB	195681
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	41.0 nM	, None	BindingDB,ChEMBL

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