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GPCR

NamePutative P2Y purinoceptor 10
SpeciesHomo sapiens (Human)
GeneP2RY10
SynonymP2Y-like receptor
P2RY10
purinergic receptor P2Y
purinergic receptor P2Y, G-protein coupled 10
purinergic receptor P2Y10
[ Show all ]
DiseaseN/A
Length339
Amino acid sequenceMANLDKYTETFKMGSNSTSTAEIYCNVTNVKFQYSLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQLSRHGSSVTRSRLMSKESGSSMIG
UniProtO00398
Protein Data BankN/A
GPCR-HGmod modelO00398
3D structure modelThis predicted structure model is from GPCR-EXP O00398.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3562166
IUPHAR165
DrugBankN/A

Ligand

NameCHEMBL3577162
Molecular formulaC25H48NO9P
IUPAC name(2S,3S)-2-amino-3-[hydroxy-[(2R)-2-hydroxy-3-[(Z)-octadec-9-enoyl]oxypropoxy]phosphoryl]oxybutanoic acid
Molecular weight537.631
Hydrogen bond acceptor10
Hydrogen bond donor4
XlogP2.6
SynonymsBDBM50096584
(2S,3S)-2-Amino-3-[[1-O-[(9Z)-9-octadecenoyl]-L-glycero-3-phospho]oxy]butanoic acid
Inchi KeyTUOGAVKNETYDTH-IKZNXBAASA-N
Inchi IDInChI=1S/C25H48NO9P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(28)33-19-22(27)20-34-36(31,32)35-21(2)24(26)25(29)30/h10-11,21-22,24,27H,3-9,12-20,26H2,1-2H3,(H,29,30)(H,31,32)/b11-10-/t21-,22+,24-/m0/s1
PubChem CID101780960
ChEMBLCHEMBL3577162
IUPHARN/A
BindingDB50096584
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50<1000.0 nMPMID25970039BindingDB,ChEMBL

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