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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 183
Species	Homo sapiens (Human)
Gene	GPR183
Synonym	EBI2 {ECO:0000303\|PubMed:8383238} lymphocyte-specific G protein-coupled receptor hEBI2 {ECO:0000303\|PubMed:22875855} GPR183 G protein-coupled receptor 183 EBI2 Epstein-Barr virus-induced G-protein coupled receptor 2 {ECO:0000303\|PubMed:8383238} EBV-induced G-protein coupled receptor 2 {ECO:0000303\|PubMed:8383238} EBV-induced G protein-coupled receptor 2 Epstein-Barr virus-induced gene 2 [ Show all ]
Disease	N/A
Length	361
Amino acid sequence	MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
UniProt	P32249
Protein Data Bank	N/A
GPCR-HGmod model	P32249
3D structure model	This predicted structure model is from GPCR-EXP P32249.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3259470
IUPHAR	81
DrugBank	N/A

Ligand

Name	CHEMBL3561208
Molecular formula	C18H23BrN2O2
IUPAC name	1-[4-[(E)-3-(4-bromophenyl)prop-2-enoyl]piperazin-1-yl]pentan-1-one
Molecular weight	379.298
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.1
Synonyms	SBI-0646759.0001 SCHEMBL16598415 SCHEMBL16598418
Inchi Key	OUIMBPCJEAEJRG-JXMROGBWSA-N
Inchi ID	InChI=1S/C18H23BrN2O2/c1-2-3-4-17(22)20-11-13-21(14-12-20)18(23)10-7-15-5-8-16(19)9-6-15/h5-10H,2-4,11-14H2,1H3/b10-7+
PubChem CID	73330407
ChEMBL	CHEMBL3561208
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	5.62 nM	PubChem BioAssay data set	ChEMBL

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