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GLASS

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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	MLS000705563
Molecular formula	C13H11N3OS
IUPAC name	6-ethyl-2-pyridin-2-yl-3H-thieno[2,3-d]pyrimidin-4-one
Molecular weight	257.311
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.5
Synonyms	6-ethyl-2-(2-pyridinyl)-3H-thieno[2,3-d]pyrimidin-4-one AKOS008024049 MCULE-3228650780 6-ethyl-2-(pyridin-2-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-one BRD-K69085837-001-11-0 SMR000232055 724745-45-3 cid_852940 6-ethyl-2-(2-pyridinyl)thieno[2,3-d]pyrimidin-4(3H)-one AR-434/42807715 6-ethyl-2-pyridin-2-yl-3H-thieno[2,3-d]pyrimidin-4-one Z55164162 AC1LGWBX HMS2521D08 6-ethyl-2-(2-pyridyl)-3H-thieno[2,3-d]pyrimidin-4-one BDBM67244 MolPort-002-849-341 CHEMBL1567827 ZINC8684349 [ Show all ]
Inchi Key	CREYUURVAPLCCE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H11N3OS/c1-2-8-7-9-12(17)15-11(16-13(9)18-8)10-5-3-4-6-14-10/h3-7H,2H2,1H3,(H,15,16,17)
PubChem CID	852940
ChEMBL	CHEMBL1567827
IUPHAR	N/A
BindingDB	67244
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	1778.3 nM	PubChem BioAssay data set	ChEMBL

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