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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	C-C chemokine receptor-like 2
Species	Homo sapiens (Human)
Gene	CCRL2
Synonym	ACR5 CRAM-B CRAM-A CKRX Chemokine receptor X Chemokine receptor CCR11 CCRL2 CCR6 CCR11 Putative MCP-1 chemokine receptor [ Show all ]
Disease	N/A
Length	344
Amino acid sequence	MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV
UniProt	O00421
Protein Data Bank	N/A
GPCR-HGmod model	O00421
3D structure model	This predicted structure model is from GPCR-EXP O00421.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2321627
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL2315923
Molecular formula	C23H25F3N6O2S
IUPAC name	N-[1-[4-hydroxy-4-(1,2-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Molecular weight	506.548
Hydrogen bond acceptor	11
Hydrogen bond donor	3
XlogP	3.0
Synonyms	CHEMBL3704097 UAISHSJUKZZNTF-UHFFFAOYSA-N N-(1-(4-hydroxy-4-(isothiazol-5-yl)cyclohexyl)azetidin-3-yl)-2-((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamide US9062048, 81 BDBM163453 SCHEMBL9998569 BDBM50425704 [ Show all ]
Inchi Key	UAISHSJUKZZNTF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H25F3N6O2S/c24-23(25,26)14-1-2-18-17(9-14)21(29-13-28-18)27-10-20(33)31-15-11-32(12-15)16-3-6-22(34,7-4-16)19-5-8-30-35-19/h1-2,5,8-9,13,15-16,34H,3-4,6-7,10-12H2,(H,31,33)(H,27,28,29)
PubChem CID	68003782
ChEMBL	CHEMBL3704097
IUPHAR	N/A
BindingDB	163453
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	22.0 nM	, None	BindingDB,ChEMBL

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