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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 5A
Species	Homo sapiens (Human)
Gene	HTR5A
Synonym	5-HT5alpha 5-HT-5 MR22 Htr5 5-HT-5A 5-HT5A 5HT5- 5-HT5A receptor 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled serotonin receptor 5A [ Show all ]
Disease	N/A
Length	357
Amino acid sequence	MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
UniProt	P47898
Protein Data Bank	N/A
GPCR-HGmod model	P47898
3D structure model	This predicted structure model is from GPCR-EXP P47898.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3426
IUPHAR	10
DrugBank	BE0004688

Ligand

Name	chlorpromazine
Molecular formula	C17H19ClN2S
IUPAC name	3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Molecular weight	318.863
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	5.2
Synonyms	NCGC00024409-06 CTK1C5154 4560 R.P. [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine(clorpromazine) NSC-167745 DSSTox_RID_76736 AB00051943_17 Phenathyl Fraction AB Aminazine Prestwick1_000064 HMS2091E06 BBL028251 Propaphenin KB-232587 BPBio1_000273 SBI-0050237.P004 KBio3_001231 Largactyl CAS-69-09-0 SPBio_002168 KSC-315-032- Megaphen Chlordelazine (chlorpromazine)[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine SR-01000000012-6 NCGC00015273-05 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine Tox21_110120 NCGC00015273-13 Chlorpromazinum [INN-Latin] 2601A Z80 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine NINDS_000624 NSC17479 Elmarin AC1L1EBT Phenothiazine, 2-chloro-10-[3-(dimethylamino)propyl]- GTPL83 Amplictil Proma HSDB 3033 BDBM50001888 QSPL 401 KBio2_002312 Largactil BSPBio_000247 SKF 2601-A KBioGR_002312 Lopac0_000249 CHEBI:3647 Spectrum3_000346 N-(3-Dimethylaminopropyl)-3-chlorophenothiazine Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine [French] 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl- Thorazine (TN) NCGC00015273-08 Chlorpromazine Tannate 2-chloro-N,N-dimethyl-10H-Phenothiazine-10-propanamine U42B7VYA4P NCGC00015273-16 Clorpromazina [Italian] CPZ 34468-21-8 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine (chlor-promazine) Novomazina DSSTox_CID_2808 AB00051943-15 Pharmakon1600-01500184 Fenactil Aminasine Prazilpromactil HMS1920M03 AX8120990 Promazil J10069 Bio1_001435 RP-4560 KBio2_005758 Largactil Oral Drops C17H19ClN2S SMR001453710 KS-00002WW5 M176 Chlor-Promanyl Spectrum_000142 NCGC00015273-03 Chlorpromanyl (discontinued) 2-chloro-10-(3-(dimethylamino)propyl)-phenothiazine Thorazine Suppositories NCGC00015273-11 Chlorpromazine;[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine 2-Cloro-10 (3-dimetilaminopropil)fenotiazina [Italian] Wintermin NCGC00024409-04 NCGC00024409-07 D00270 4560 Rp hydrochloride NSC-756689 DTXSID0022808 AB00051943_18 Phenothiazine hydrochloride FT-0653683 Ampliactil Prestwick2_000064 HMS3430C19 BC 135 Prozil KBio1_000624 BPBio1_001181 SC-50091 KBio3_002792 Lomazine (Salt/Mix) CCG-40059 SPECTRUM1500184 KUC112482N MLS003166901 Chlorderazin STK182870 NCGC00015273-06 Chlorpromazine (USP/INN) 2-chloro-10-[3-(dimethylamino)propyl]- Tox21_110120_1 NCGC00015273-14 Clorpromazina 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine ZINC44027 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine hydrochloride Norcozine (Salt/Mix) DB00477 NSC756689 Epitope ID:136898 AKOS001490972 Plegomasine Hibernal (Salt/Mix) AN-41563 Promactil I14-6226 Bio1_000457 QTL1_000021 KBio2_003190 Largactil (TN) BSPBio_002011 SKF 2601A KBioSS_000622 LS-105361 Spectrum4_000283 NCGC00015273-01 Chloropromazine 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, radical ion(1+) Thorazine hydrochloride NCGC00015273-09 Chlorpromazine [USAN:INN:BAN] 2-Chloropromazine UNII-U42B7VYA4P NCGC00015273-17 cMAP_000017 NCGC00024409-05 Cromedazine 4560 R.P [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine( Chlorpromazine) NSC 167745 DSSTox_GSID_22808 AB00051943-16 Phenactyl Fenaktyl Aminazin Prestwick0_000064 HMS2089C12 BAS 00010434 Propaphen JHICC02042 Biomol-NT_000020 Sanopron KBio2_007448 Largactilothiazine CAS-50-53-3 SPBio_001111 KS-5101 MCULE-5976054678 Chlor-PZ (chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine SR-01000000012-5 NCGC00015273-04 Chlorpromazin 2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine Torazina NCGC00015273-12 Chlorpromazinum 2601-A WLN: T C666 BN ISJ B3N1&1 EG NCGC00024409-08 D01ZII 50-53-3 NSC167745 EINECS 200-045-8 AB0015094 Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)- GG 407 Amplicitil Prestwick3_000064 HMS501P06 BCP03610 Psychozine KBio2_000622 L000182 BRD-K89997465-001-05-3 SCHEMBL8321 KBioGR_000806 Lopac-C-8138 CCRIS 3711 Spectrum2_001156 MolPort-001-727-953 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine 10-(3-Dimethylaminopropyl)-2-chlorophenothiazine Thorazine NCGC00015273-07 Chlorpromazine cation radical 2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine Tranzine (Salt/Mix) NCGC00015273-15 Clorpromazina [INN-Spanish] 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine # ZPEIMTDSQAKGNT-UHFFFAOYSA-N 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Novo-Chlorpromazine DivK1c_000624 AB00051943 Oprea1_110255 Esmind ALBB-022464 Plegomazin HL 5746 API0001970 Promapar IDI1_000624 Bio1_000946 R1242 KBio2_004880 Largactil Liquid C06906 SKF-2601 KBioSS_002314 M-1209 CHEMBL71 Spectrum5_000717 NCGC00015273-02 Chlorpromados 1N,1N-dimethyl-3-(2-chloro-10H-10-phenothiazinyl)-1-propanamine Thorazine Spansule NCGC00015273-10 Chlorpromazine [USP:INN:BAN] 2-Cloro-10 (3-dimetilaminopropil)fenotiazina Unitensen NCGC00015273-19 Contomin [ Show all ]
Inchi Key	ZPEIMTDSQAKGNT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
PubChem CID	2726
ChEMBL	CHEMBL71
IUPHAR	83
BindingDB	50001888
DrugBank	DB00477
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	118.0 nM	http://pdsp.med.unc.edu/pdsp.php	PDSP

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