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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 5A
Species	Homo sapiens (Human)
Gene	HTR5A
Synonym	5-HT5alpha 5-HT-5 MR22 Htr5 5-HT-5A 5-HT5A 5HT5- 5-HT5A receptor 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled serotonin receptor 5A [ Show all ]
Disease	N/A
Length	357
Amino acid sequence	MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
UniProt	P47898
Protein Data Bank	N/A
GPCR-HGmod model	P47898
3D structure model	This predicted structure model is from GPCR-EXP P47898.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3426
IUPHAR	10
DrugBank	BE0004688

Ligand

Name	chlorpromazine
Molecular formula	C17H19ClN2S
IUPAC name	3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Molecular weight	318.863
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	5.2
Synonyms	Pharmakon1600-01500184 CPZ 34468-21-8 Prazilpromactil DSSTox_CID_2808 AB00051943-15 Promazil Fenactil Aminasine RP-4560 HMS1920M03 Largactil Oral Drops AX8120990 SMR001453710 J10069 M176 Bio1_001435 Spectrum_000142 KBio2_005758 NCGC00015273-03 C17H19ClN2S Thorazine Suppositories KS-00002WW5 NCGC00015273-11 Chlor-Promanyl Wintermin NCGC00024409-04 Chlorpromanyl (discontinued) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine (chlor-promazine) 2-chloro-10-(3-(dimethylamino)propyl)-phenothiazine Novomazina Chlorpromazine;[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine 2-Cloro-10 (3-dimetilaminopropil)fenotiazina [Italian] 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine Phenothiazine hydrochloride D00270 4560 Rp hydrochloride Prestwick2_000064 DTXSID0022808 AB00051943_18 Prozil FT-0653683 Ampliactil SC-50091 HMS3430C19 Lomazine (Salt/Mix) BC 135 SPECTRUM1500184 KBio1_000624 MLS003166901 BPBio1_001181 STK182870 KBio3_002792 NCGC00015273-06 CCG-40059 Tox21_110120_1 KUC112482N NCGC00015273-14 Chlorderazin ZINC44027 NCGC00024409-07 Chlorpromazine (USP/INN) 2-chloro-10-[3-(dimethylamino)propyl]- NSC-756689 Clorpromazina NSC756689 cMAP_000017 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine Plegomasine DB00477 Promactil Epitope ID:136898 AKOS001490972 QTL1_000021 Hibernal (Salt/Mix) Largactil (TN) AN-41563 SKF 2601A I14-6226 LS-105361 Bio1_000457 Spectrum4_000283 KBio2_003190 NCGC00015273-01 BSPBio_002011 Thorazine hydrochloride KBioSS_000622 NCGC00015273-09 UNII-U42B7VYA4P NCGC00015273-17 Chloropromazine [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine hydrochloride 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, radical ion(1+) Norcozine (Salt/Mix) Chlorpromazine [USAN:INN:BAN] 2-Chloropromazine 2601-A Phenactyl Cromedazine 4560 R.P Prestwick0_000064 DSSTox_GSID_22808 AB00051943-16 Propaphen Fenaktyl Aminazin Sanopron HMS2089C12 Largactilothiazine BAS 00010434 SPBio_001111 JHICC02042 MCULE-5976054678 Biomol-NT_000020 SR-01000000012-5 KBio2_007448 NCGC00015273-04 CAS-50-53-3 Torazina KS-5101 NCGC00015273-12 Chlor-PZ WLN: T C666 BN ISJ B3N1&1 EG (chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine NCGC00024409-05 Chlorpromazin [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine( Chlorpromazine) 2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine NSC 167745 Chlorpromazinum 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine # Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)- D01ZII 50-53-3 Prestwick3_000064 EINECS 200-045-8 AB0015094 Psychozine GG 407 L000182 Amplicitil SCHEMBL8321 HMS501P06 Lopac-C-8138 BCP03610 Spectrum2_001156 KBio2_000622 MolPort-001-727-953 BRD-K89997465-001-05-3 Thorazine KBioGR_000806 NCGC00015273-07 CCRIS 3711 Tranzine (Salt/Mix) NCGC00015273-15 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine ZPEIMTDSQAKGNT-UHFFFAOYSA-N 10-(3-Dimethylaminopropyl)-2-chlorophenothiazine NCGC00024409-08 Chlorpromazine cation radical 2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine NSC167745 Clorpromazina [INN-Spanish] Oprea1_110255 Contomin 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine Plegomazin DivK1c_000624 AB00051943 Promapar Esmind ALBB-022464 R1242 HL 5746 Largactil Liquid API0001970 SKF-2601 IDI1_000624 M-1209 Bio1_000946 Spectrum5_000717 KBio2_004880 NCGC00015273-02 C06906 Thorazine Spansule KBioSS_002314 NCGC00015273-10 CHEMBL71 Unitensen NCGC00015273-19 Chlorpromados [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine 1N,1N-dimethyl-3-(2-chloro-10H-10-phenothiazinyl)-1-propanamine Novo-Chlorpromazine Chlorpromazine [USP:INN:BAN] 2-Cloro-10 (3-dimetilaminopropil)fenotiazina 2601A Phenathyl CTK1C5154 4560 R.P. Prestwick1_000064 DSSTox_RID_76736 AB00051943_17 Propaphenin Fraction AB Aminazine SBI-0050237.P004 HMS2091E06 Largactyl BBL028251 SPBio_002168 KB-232587 Megaphen BPBio1_000273 SR-01000000012-6 KBio3_001231 NCGC00015273-05 CAS-69-09-0 Tox21_110120 KSC-315-032- NCGC00015273-13 Chlordelazine Z80 (chlorpromazine)[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine NCGC00024409-06 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine(clorpromazine) 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine NSC-167745 Chlorpromazinum [INN-Latin] Clorpromazina [Italian] 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine Phenothiazine, 2-chloro-10-[3-(dimethylamino)propyl]- Proma Elmarin AC1L1EBT QSPL 401 GTPL83 Largactil Amplictil SKF 2601-A HSDB 3033 Lopac0_000249 BDBM50001888 Spectrum3_000346 KBio2_002312 N-(3-Dimethylaminopropyl)-3-chlorophenothiazine BSPBio_000247 Thorazine (TN) KBioGR_002312 NCGC00015273-08 CHEBI:3647 U42B7VYA4P NCGC00015273-16 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine [French] [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl- NINDS_000624 Chlorpromazine Tannate 2-chloro-N,N-dimethyl-10H-Phenothiazine-10-propanamine NSC17479 [ Show all ]
Inchi Key	ZPEIMTDSQAKGNT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
PubChem CID	2726
ChEMBL	CHEMBL71
IUPHAR	83
BindingDB	50001888
DrugBank	DB00477
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	118.0 nM	http://pdsp.med.unc.edu/pdsp.php	PDSP

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