Zhang Lab

National University of Singapore

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●D-I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●D-QUARK ●DRfold ●DRfold2 ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●ATGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred ●TCRfinder

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●TM-search ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●DeepMSA2 ●rMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●HPmod ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
Go back to previous page.

GPCR

Name	Putative gonadotropin-releasing hormone II receptor
Species	Homo sapiens (Human)
Gene	GNRHR2
Synonym	Type II GnRH receptor gonadotropin-releasing hormone (type 2) receptor 2, pseudogene gonadotropin-releasing hormone (type 2) receptor 2 GnRH2 receptor GnRH-II-R GnRH II receptor Type II GnRHR [ Show all ]
Disease	N/A
Length	292
Amino acid sequence	MSAGNGTPWDATWNITVQWLAVDIACRTLMFLKLMATYSAAFLPVVIGLDRQAAVLNPLGSRSGVRKLLGAAWGLSFLLAFPQLFLFHTVHCAGPVPFTQCVTKGSFKAQWQETTYNLFTFCCLFLLPLTAMAICYSRIVLSVSRPQTRKGSHAPAGEFALPRSFDNCPRVRLRALRLALLILLTFILCWTPYYLLGMWYWFSPTMLTEVPPSLSHILFLLGLLNAPLDPLLYGAFTLGCRRGHQELSIDSSKEGSGRMLQEEIHAFRQLEVQKTVTSRRAGETKGISITSI
UniProt	Q96P88
Protein Data Bank	N/A
GPCR-HGmod model	Q96P88
3D structure model	This predicted structure model is from GPCR-EXP Q96P88.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	N/A
DrugBank	BE0000472

Ligand

Name	Dirigestran
Molecular formula	C55H75N17O13
IUPAC name	N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Molecular weight	1182.31
Hydrogen bond acceptor	15
Hydrogen bond donor	16
XlogP	-2.4
Synonyms	L000690 LHFSHRH Luteinizing hormone releasing hormone Luteinizing hormone-releasing hormone (swin) N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[(2-azanyl-2-oxidanylidene-ethyl)carbamoyl]pyrrolidin-1-yl]-5-[bis(azanyl)methylideneamino]-1-oxidanylidene-pentan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]amino]-3-(4-hydroxyphenyl)-1-o AC1L1VXF pyroGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 DB00644 Synthetic gonadotropin-releasing hormone FSH-Releasing Hormone Synthetic LH-RH/FSH-RH Gonadorelin (INN) Gonadotropin, luteinizing hormone-releasing hormone, synthetic LH-Releasing factor (pig) LS-174422 Luteinizing hormone-releasing factor (pig) Mammalian GnRH NCGC00182043-01 C07607 Relisorm l EINECS 251-553-1 Synthetic LH-releasing factor Gn-RH Gonadorelina HOE 471 I06-0360 LH-RH (swine) Lutamin Luteinizing hormone-releasing factor (swine) MammalianGnRH 9034-40-6 Porchine LH-RH D04ODH Synthetic gonadoliberin Fertagyl (TN) Synthetic LH-RF Gonadoliberin, Luliberin Gonadorelinum LFRH LHRH Luteinizing hormone releasing hormone human Lutrefact N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[[(2-amino-2-oxoethyl)amino]-oxomethyl]-1-pyrrolidinyl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropa AN-7551 Relefact Synthetic LH-FSH releasing hormone FT-0628048 Synthetic LRF Gonadorelin decapeptide Gonadotropin-releasing hormone LH-Releasing hormone (porcine) Luforan Luteinizing hormone-releasing factor (rat) Mammalian gonadotropin-releasing hormone Ovine gonadotropin-releasing hormone C55H75N17O13 Synthetic decapeptide FSH/LH-RH Factrel Synthetic LH-releasing hormone GnRH-I Gonadorelina [INN-Spanish] Human LH-RH Kryptocur LHFSH Releasing Hormone LUTEINIZING HORMONE Luteinizing hormone-releasing hormone MT-BT A821811 Porcine LH-releasing factor Synthetic gonadotropic hormone-releasing hormone Follicle-stimulating hormone-releasing factor (pig) Synthetic LH-RH GONADORELIN Gonadorelinum [INN-Latin] LH-FSH Releasing Hormone LHRH, human Luteinizing hormone-releasing factor (human) Lutrepulse KIT N-[2-[[2-[[2-[[2-[[2-[[1-[[1-[2-[(2-amino-2-oxo-ethyl)carbamoyl]pyrrolidine-1-carbonyl]-4-guanidino-butyl]carbamoyl]-3-methyl-butyl]amino]-2-oxo-ethyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-(1H-indol-3 AY-24031 Relisorm Dirigestran Spofa Synthetic LH-FSH-RH Glycinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-L-prolyl- XLXSAKCOAKORKW-UHFFFAOYSA-N Gonadorelin [INN:BAN] Gonadotropin-releasing hormone I LH-RH Lutal Luteinizing hormone-releasing factor (sheep) Mammalian LH-RH 6918-09-8 Ovine LH-RH CHEMBL1981292 Synthetic Gn-RH Fertagyl Synthetic LH-releasing hormone/FSH-releasing hormone Gonadoliberin I Gonadoreline Hypocrine [ Show all ]
Inchi Key	XLXSAKCOAKORKW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C55H75N17O13/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60)
PubChem CID	36523
ChEMBL	N/A
IUPHAR	N/A
BindingDB	N/A
DrugBank	DB00644
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank

zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417