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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Histamine H4 receptor
Species	Homo sapiens (Human)
Gene	HRH4
Synonym	Pfi-013 SP9144 HH4R H4R H4 receptor GPRv53 GPCR105 G-protein coupled receptor 105 AXOR35 [ Show all ]
Disease	Allergic rhinitis Asthma Inflammatory disease Rheumatoid arthritis
Length	390
Amino acid sequence	MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
UniProt	Q9H3N8
Protein Data Bank	N/A
GPCR-HGmod model	Q9H3N8
3D structure model	This predicted structure model is from GPCR-EXP Q9H3N8.
BioLiP	N/A
Therapeutic Target Database	T26500
ChEMBL	CHEMBL3759
IUPHAR	265
DrugBank	BE0000146

Ligand

Name	CHEMBL2047444
Molecular formula	C15H19N3O
IUPAC name	[(3R)-3-(methylamino)pyrrolidin-1-yl]-(7-methyl-1H-indol-2-yl)methanone
Molecular weight	257.337
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	2.0
Synonyms	BDBM50387431 SCHEMBL4328702
Inchi Key	AEPVGIPVZCQCFW-GFCCVEGCSA-N
Inchi ID	InChI=1S/C15H19N3O/c1-10-4-3-5-11-8-13(17-14(10)11)15(19)18-7-6-12(9-18)16-2/h3-5,8,12,16-17H,6-7,9H2,1-2H3/t12-/m1/s1
PubChem CID	24764570
ChEMBL	CHEMBL2047444
IUPHAR	N/A
BindingDB	50387431
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	630.96 nM	PMID22749391	BindingDB,ChEMBL

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