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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H4 receptor
Species	Homo sapiens (Human)
Gene	HRH4
Synonym	Pfi-013 SP9144 HH4R H4R H4 receptor GPRv53 GPCR105 G-protein coupled receptor 105 AXOR35 [ Show all ]
Disease	Allergic rhinitis Asthma Inflammatory disease Rheumatoid arthritis
Length	390
Amino acid sequence	MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
UniProt	Q9H3N8
Protein Data Bank	N/A
GPCR-HGmod model	Q9H3N8
3D structure model	This predicted structure model is from GPCR-EXP Q9H3N8.
BioLiP	N/A
Therapeutic Target Database	T26500
ChEMBL	CHEMBL3759
IUPHAR	265
DrugBank	BE0000146

Ligand

Name	CHEMBL3220892
Molecular formula	C17H23N5O
IUPAC name	N-[N'-(3-imidazol-1-ylpropyl)carbamimidoyl]-3-phenylbutanamide
Molecular weight	313.405
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	1.7
Synonyms	N/A
Inchi Key	AEOZDVJZTYYDHL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H23N5O/c1-14(15-6-3-2-4-7-15)12-16(23)21-17(18)20-8-5-10-22-11-9-19-13-22/h2-4,6-7,9,11,13-14H,5,8,10,12H2,1H3,(H3,18,20,21,23)
PubChem CID	90667434
ChEMBL	CHEMBL3220892
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1000.0 nM	MedChemComm, (2014) 5:1:72	ChEMBL
Intrinsic activity	0.77 -	MedChemComm, (2014) 5:1:72	ChEMBL

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