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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Neuropeptide Y receptor type 2
Species	Homo sapiens (Human)
Gene	NPY2R
Synonym	NPY2-R NPY-Y2 receptor neuropeptide Y receptor type 2 Y2 receptor
Disease	Diabetes Metabolic disorders Obesity
Length	381
Amino acid sequence	MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
UniProt	P49146
Protein Data Bank	N/A
GPCR-HGmod model	P49146
3D structure model	This predicted structure model is from GPCR-EXP P49146.
BioLiP	N/A
Therapeutic Target Database	T10670
ChEMBL	CHEMBL4018
IUPHAR	306
DrugBank	BE0002419

Ligand

Name	CHEMBL2030159
Molecular formula	C26H28N2O2S
IUPAC name	4-[hydroxy(diphenyl)methyl]-N-(3-methoxyphenyl)piperidine-1-carbothioamide
Molecular weight	432.582
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	4.8
Synonyms	STK448243 MolPort-001-594-266 (1-{[(3-methoxyphenyl)amino]thioxomethyl}(4-piperidyl))diphenylmethan-1-ol ZINC16315399 AKOS003329784 ST50856382 4-[hydroxy(diphenyl)methyl]-N-(3-methoxyphenyl)piperidine-1-carbothioamide BDBM50384198 MCULE-6786180577 [ Show all ]
Inchi Key	BIKYNDCDUMNFSQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H28N2O2S/c1-30-24-14-8-13-23(19-24)27-25(31)28-17-15-22(16-18-28)26(29,20-9-4-2-5-10-20)21-11-6-3-7-12-21/h2-14,19,22,29H,15-18H2,1H3,(H,27,31)
PubChem CID	17376722
ChEMBL	CHEMBL2030159
IUPHAR	N/A
BindingDB	50384198
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	8162.0 nM	PMID22607676	BindingDB,ChEMBL

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