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Name | Sphingosine 1-phosphate receptor 4 |
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Species | Homo sapiens (Human) |
Gene | S1PR4 |
Synonym | S1P4 receptor S1P4 S1P receptor Edg-6 S1P receptor 4 endothelial differentiation, G protein-coupled receptor 6 [ Show all ] |
Disease | N/A |
Length | 384 |
Amino acid sequence | MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI |
UniProt | O95977 |
Protein Data Bank | N/A |
GPCR-HGmod model | O95977 |
3D structure model | This predicted structure model is from GPCR-EXP O95977. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3230 |
IUPHAR | 278 |
DrugBank | N/A |
Name | SCHEMBL14338632 |
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Molecular formula | C19H34NO4P |
IUPAC name | [3-amino-2-hydroxy-5-(4-octylphenyl)pentyl]phosphonic acid |
Molecular weight | 371.458 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 4 |
XlogP | 1.0 |
Synonyms | N/A |
Inchi Key | BGPIKLDZOZBUEW-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C19H34NO4P/c1-2-3-4-5-6-7-8-16-9-11-17(12-10-16)13-14-18(20)19(21)15-25(22,23)24/h9-12,18-19,21H,2-8,13-15,20H2,1H3,(H2,22,23,24) |
PubChem CID | 10172545 |
ChEMBL | CHEMBL112655 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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IC50 | 140.0 nM | PMID15149705 | ChEMBL |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417