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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Sphingosine 1-phosphate receptor 4
Species	Homo sapiens (Human)
Gene	S1PR4
Synonym	S1P4 receptor S1P4 S1P receptor Edg-6 S1P receptor 4 endothelial differentiation, G protein-coupled receptor 6 Endothelial differentiation G-protein coupled receptor 6 edg6 Sphingosine 1-phosphate receptor Edg-6 [ Show all ]
Disease	N/A
Length	384
Amino acid sequence	MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI
UniProt	O95977
Protein Data Bank	N/A
GPCR-HGmod model	O95977
3D structure model	This predicted structure model is from GPCR-EXP O95977.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3230
IUPHAR	278
DrugBank	N/A

Ligand

Name	SR-02000000242
Molecular formula	C19H15Cl2NO2
IUPAC name	5-(2,5-dichlorophenyl)-N-(2,5-dimethylphenyl)furan-2-carboxamide
Molecular weight	360.234
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	5.8
Synonyms	Oprea1_143483 AC1LLQ4X BDBM62398 SR-02000000242-1 5-(2,5-dichlorophenyl)-N-(2,5-dimethylphenyl)-2-furamide cid_1114196 5-[2,5-bis(chloranyl)phenyl]-N-(2,5-dimethylphenyl)furan-2-carboxamide Oprea1_396142 AKOS000548122 ZINC848990 5-(2,5-dichlorophenyl)-N-(2,5-dimethylphenyl)-2-furancarboxamide MolPort-000-226-934 5-(2,5-Dichloro-phenyl)-furan-2-carboxylic acid (2,5-dimethyl-phenyl)-amide BAS 01064652 CHEMBL1473443 5-(2,5-dichlorophenyl)-N-(2,5-dimethylphenyl)furan-2-carboxamide [ Show all ]
Inchi Key	ADEIWISNTUOOEM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H15Cl2NO2/c1-11-3-4-12(2)16(9-11)22-19(23)18-8-7-17(24-18)14-10-13(20)5-6-15(14)21/h3-10H,1-2H3,(H,22,23)
PubChem CID	1114196
ChEMBL	CHEMBL1473443
IUPHAR	N/A
BindingDB	62398
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	165.0 nM	, PMID21570287, PubChem BioAssay data set	BindingDB,ChEMBL

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