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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Rattus norvegicus (Rat)
Gene	Hcar2
Synonym	Protein PUMA-G Nicotinic acid receptor Nic1 Niacr1 niacin receptor 1 HCA2 receptor G-protein coupled receptor HM74A G-protein coupled receptor HM74 G-protein coupled receptor 109A G-protein coupled receptor 109 G protein-coupled receptor 109A PUMAG [ Show all ]
Disease	N/A for non-human GPCRs
Length	360
Amino acid sequence	MSKQNHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVQNWDWRFGSIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGITIGLTVHLLYTDMMTRNGDANLCSSFSICYTFRWHDAMFLLEFFLPLGIILFCSGRIIWSLRQRQMDRHVKIKRAINFIMVVAIVFVICFLPSVAVRIRIFWLLYKHNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRRKTLGEPDNNRSTSVELTGDPSTIRSIPGALMTDPSEPGSPPYLASTSR
UniProt	Q80Z39
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4731
IUPHAR	312
DrugBank	N/A

Ligand

Name	MK-0354
Molecular formula	C7H8N6
IUPAC name	3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole
Molecular weight	176.183
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	0.2
Synonyms	KB-78878 UNII-4U62D8JYIQ 1,4,5,6-Tetrahydro-3-(1H-tetrazol-5-yl)cyclopenta[c]pyrazole(MK-0354) 5-{1H,4H,5H,6H-CYCLOPENTA[C]PYRAZOL-3-YL}-1H-1,2,3,4-TETRAZOLE CHEMBL456145 D0A5MR 3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole 851776-28-8 GTPL5784 NCGC00263122-02 3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[d]pyrazole BDBM50273099 LTQYSJKGRPGMPO-UHFFFAOYSA-N ZINC38312374 1,4,5,6-tetrahydro-3-(2H-tetrazol-5-yl)Cyclopentapyrazole CS-4589 DA-02747 MolPort-009-683-033 3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopentapyrazole AKOS030526928 HY-13008 SCHEMBL1875705 1,4,5,6-Tetrahydro-3-(1H-tetrazol-5-yl)cyclopenta[c]pyrazole 4U62D8JYIQ MK 0354 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole Cyclopenta(C)pyrazole, 1,4,5,6-tetrahydro-3-(1H-tetrazol-5-yl)- NCGC00263122-01 3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole BCP18112 [ Show all ]
Inchi Key	LTQYSJKGRPGMPO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C7H8N6/c1-2-4-5(3-1)8-9-6(4)7-10-12-13-11-7/h1-3H2,(H,8,9)(H,10,11,12,13)
PubChem CID	11159621
ChEMBL	CHEMBL456145
IUPHAR	5784
BindingDB	50273099
DrugBank	DB05939
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	2300.0 nM	PMID18665582	BindingDB,ChEMBL
Efficacy	38.0 %	PMID18665582	ChEMBL

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