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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Sphingosine 1-phosphate receptor 4
Species	Homo sapiens (Human)
Gene	S1PR4
Synonym	S1P4 receptor S1P4 S1P receptor Edg-6 S1P receptor 4 endothelial differentiation, G protein-coupled receptor 6 Endothelial differentiation G-protein coupled receptor 6 edg6 Sphingosine 1-phosphate receptor Edg-6 [ Show all ]
Disease	N/A
Length	384
Amino acid sequence	MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI
UniProt	O95977
Protein Data Bank	N/A
GPCR-HGmod model	O95977
3D structure model	This predicted structure model is from GPCR-EXP O95977.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3230
IUPHAR	278
DrugBank	N/A

Ligand

Name	CHEMBL210301
Molecular formula	C20H21N3O4
IUPAC name	3-[3-methyl-4-[5-(6-propan-2-yloxypyridin-3-yl)-1,2,4-oxadiazol-3-yl]phenyl]propanoic acid
Molecular weight	367.405
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.6
Synonyms	3-(4-(5-(6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl)-3-methylphenyl)propanoic acid BDBM50186922
Inchi Key	AZBMSTQSHHAVDB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H21N3O4/c1-12(2)26-17-8-6-15(11-21-17)20-22-19(23-27-20)16-7-4-14(10-13(16)3)5-9-18(24)25/h4,6-8,10-12H,5,9H2,1-3H3,(H,24,25)
PubChem CID	44412659
ChEMBL	CHEMBL210301
IUPHAR	N/A
BindingDB	50186922
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<10000.0 nM	PMID16697189	BindingDB,ChEMBL

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