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GPCR

Name	Neuropeptide Y receptor type 2
Species	Homo sapiens (Human)
Gene	NPY2R
Synonym	NPY2-R NPY-Y2 receptor neuropeptide Y receptor type 2 Y2 receptor
Disease	Diabetes Metabolic disorders Obesity
Length	381
Amino acid sequence	MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
UniProt	P49146
Protein Data Bank	N/A
GPCR-HGmod model	P49146
3D structure model	This predicted structure model is from GPCR-EXP P49146.
BioLiP	N/A
Therapeutic Target Database	T10670
ChEMBL	CHEMBL4018
IUPHAR	306
DrugBank	BE0002419

Ligand

Name	MLS000552453
Molecular formula	C15H18Cl2N4O2S
IUPAC name	4-[2-(2,4-dichlorophenoxy)ethylsulfanyl]-6-ethoxy-N,N-dimethyl-1,3,5-triazin-2-amine
Molecular weight	389.295
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	4.9
Synonyms	CHEMBL1431004 STK100210 4-[2-(2,4-dichlorophenoxy)ethylthio]-6-ethoxy-N,N-dimethyl-1,3,5-triazin-2-amine MCULE-7431671989 {4-[2-(2,4-Dichloro-phenoxy)-ethylsulfanyl]-6-ethoxy-[1,3,5]triazin-2-yl}-dimethyl-amine BDBM42493 REGID_for_CID_1894428 371950-76-4 cid_1894428 ZINC2268078 4-[2-[2,4-bis(chloranyl)phenoxy]ethylsulfanyl]-6-ethoxy-N,N-dimethyl-1,3,5-triazin-2-amine AC1LZ7HI SMR000145968 4-[2-(2,4-dichlorophenoxy)ethylsulfanyl]-6-ethoxy-N,N-dimethyl-1,3,5-triazin-2-amine HMS2539O13 [4-[2-(2,4-dichlorophenoxy)ethylthio]-6-ethoxy-s-triazin-2-yl]-dimethyl-amine 4-{[2-(2,4-dichlorophenoxy)ethyl]sulfanyl}-6-ethoxy-N,N-dimethyl-1,3,5-triazin-2-amine AKOS003593280 MolPort-002-547-181 [ Show all ]
Inchi Key	AYTQUIGQFYRMRK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H18Cl2N4O2S/c1-4-22-14-18-13(21(2)3)19-15(20-14)24-8-7-23-12-6-5-10(16)9-11(12)17/h5-6,9H,4,7-8H2,1-3H3
PubChem CID	1894428
ChEMBL	CHEMBL1431004
IUPHAR	N/A
BindingDB	42493
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	5523.0 nM	PubChem BioAssay data set	ChEMBL

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