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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Platelet-activating factor receptor
Species	Cavia porcellus (Guinea pig)
Gene	PTAFR
Synonym	PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	342
Amino acid sequence	MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProt	P21556
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5136
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL133457
Molecular formula	C27H29N5O
IUPAC name	2-[4-[3-(benzhydrylamino)propanoyl]piperazin-1-yl]-2-pyridin-4-ylacetonitrile
Molecular weight	439.563
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	2.6
Synonyms	{4-[3-(Benzhydryl-amino)-propionyl]-piperazin-1-yl}-pyridin-4-yl-acetonitrile; hydrate; diethylether BDBM50003556 SCHEMBL9852953
Inchi Key	KQBOPEOVYVGIOG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H29N5O/c28-21-25(22-11-14-29-15-12-22)31-17-19-32(20-18-31)26(33)13-16-30-27(23-7-3-1-4-8-23)24-9-5-2-6-10-24/h1-12,14-15,25,27,30H,13,16-20H2
PubChem CID	10026204
ChEMBL	CHEMBL133457
IUPHAR	N/A
BindingDB	50003556
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	55.0 nM	PMID1433215	BindingDB,ChEMBL

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