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GPCR

NamePlatelet-activating factor receptor
SpeciesRattus norvegicus (Rat)
GenePtafr
SynonymAGEPC receptor
PAF receptor
PAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length341
Amino acid sequenceMEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPSKKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGITLSLVIWISIAATASYFLATDSTNVVPKKDGSGNITRCFEHYEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRPVRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQTPVLPLKN
UniProtP46002
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4127
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL133457
Molecular formulaC27H29N5O
IUPAC name2-[4-[3-(benzhydrylamino)propanoyl]piperazin-1-yl]-2-pyridin-4-ylacetonitrile
Molecular weight439.563
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP2.6
SynonymsSCHEMBL9852953
{4-[3-(Benzhydryl-amino)-propionyl]-piperazin-1-yl}-pyridin-4-yl-acetonitrile; hydrate; diethylether
BDBM50003556
Inchi KeyKQBOPEOVYVGIOG-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H29N5O/c28-21-25(22-11-14-29-15-12-22)31-17-19-32(20-18-31)26(33)13-16-30-27(23-7-3-1-4-8-23)24-9-5-2-6-10-24/h1-12,14-15,25,27,30H,13,16-20H2
PubChem CID10026204
ChEMBLCHEMBL133457
IUPHARN/A
BindingDB50003556
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
ID500.037 mg.kg-1PMID1433215ChEMBL

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