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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Alpha-1B adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA1B
Synonym	alpha1B-adrenoceptor alpha1B-adrenergic receptor Alpha-1B adrenoreceptor Alpha-1B adrenoceptor alpha 1B-adrenoreceptor alpha 1B-adrenoceptor adrenergic receptor adrenergic alpha 1B receptor [ Show all ]
Disease	Psychiatric disorder Hypertension Exogenous obesity Attention deficit hyperactivity disorder
Length	520
Amino acid sequence	MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLTEPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
UniProt	P35368
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T29500
ChEMBL	CHEMBL232
IUPHAR	23
DrugBank	BE0000575

Ligand

Name	Glemanserin
Molecular formula	C20H25NO
IUPAC name	phenyl-[1-(2-phenylethyl)piperidin-4-yl]methanol
Molecular weight	295.426
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.8
Synonyms	BDBM50004327 DTXSID4042624 L002081 PDSP1_001574 AC1L2GSP Glemanserin (USAN/INN) MDL 11,939phenyl[1-(2-phenylethyl)piperidin-4-yl]methanol phenyl-[1-(2-phenylethyl)piperidin-4-yl]methanol ( inverted exclamation markA)-1-phenethyl-a-phenyl-4-piperidinemethanol alpha-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol AN-24938 D04320 HMS3266L14 MDL-11939 SR-01000597432 (1-phenethylpiperidin-4-yl)(phenyl)methanol 4-Piperidinemethanol,a-phenyl-1-(2-phenylethyl)- BRD-A62057054-001-01-5 FT-0703731 LS-172057 PDSP2_001558 107703-78-6 AC1Q771C alpha-phenyl-[1-(2-phenylethyl )]-4-piperidinemethanol CHEMBL18972 Glemanserin [USAN:INN] Mdl 11939 RT-013670 (+-)-1-Phenethyl-alpha-phenyl-4-piperidinemethanol 4-Piperidinemethanol, alpha-phenyl-1-(2-phenylethyl)- AXNGJCOYCMDPQG-UHFFFAOYSA-N D05MFO J-002002 MolPort-003-983-619 SR-01000597432-1 (1-phenethylpiperidin-4-yl)-phenylmethanol CHEBI:91790 MDL 11,939 phenyl-[1-(2-phenylethyl)-4-piperidyl]methanol 132553-86-7 AKOS024458672 alpha-phenyl-[1-(2-phenylethyl)]-4-piperidinemethanol CTK8D3348 GTPL186 Mdl-11,939 SCHEMBL120012 (1-Phenethyl-piperidin-4-yl)-phenyl-methanol 4-Piperidinemethanol, alpha-phenyl-1-(2-phenylethyl)-, (+-)- [ Show all ]
Inchi Key	AXNGJCOYCMDPQG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H25NO/c22-20(18-9-5-2-6-10-18)19-12-15-21(16-13-19)14-11-17-7-3-1-4-8-17/h1-10,19-20,22H,11-16H2
PubChem CID	71781
ChEMBL	CHEMBL18972
IUPHAR	186
BindingDB	50004327
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1579.0 nM	PMID15999145	PDSP,BindingDB

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