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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Rattus norvegicus (Rat)
Gene	Htr2b
Synonym	stomach fundus serotonin receptor serotonin receptor 2B 5-HT-2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 5-HT2F 5-HT2B receptor 5-HT2B 5-HT-2F {ECO:0000303\|PubMed:1331748} Stomach fundus serotonin receptor {ECO:0000303\|PubMed:1505525} [ Show all ]
Disease	N/A for non-human GPCRs
Length	479
Amino acid sequence	MASSYKMSEQSTISEHILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSSPEKMVMLDGSHKDKILPNSTDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTKHGIRNGINPAMYQSPVRLRSSTIQSSSIILLNTFLTENDGDKVEDQVSYI
UniProt	P30994
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL323
IUPHAR	7
DrugBank	N/A

Ligand

Name	Glemanserin
Molecular formula	C20H25NO
IUPAC name	phenyl-[1-(2-phenylethyl)piperidin-4-yl]methanol
Molecular weight	295.426
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.8
Synonyms	RT-013670 (+-)-1-Phenethyl-alpha-phenyl-4-piperidinemethanol 4-Piperidinemethanol, alpha-phenyl-1-(2-phenylethyl)- alpha-phenyl-[1-(2-phenylethyl )]-4-piperidinemethanol CHEMBL18972 Glemanserin [USAN:INN] Mdl 11939 MolPort-003-983-619 SR-01000597432-1 (1-phenethylpiperidin-4-yl)-phenylmethanol AXNGJCOYCMDPQG-UHFFFAOYSA-N D05MFO J-002002 phenyl-[1-(2-phenylethyl)-4-piperidyl]methanol 132553-86-7 AKOS024458672 CHEBI:91790 MDL 11,939 SCHEMBL120012 (1-Phenethyl-piperidin-4-yl)-phenyl-methanol 4-Piperidinemethanol, alpha-phenyl-1-(2-phenylethyl)-, (+-)- alpha-phenyl-[1-(2-phenylethyl)]-4-piperidinemethanol CTK8D3348 GTPL186 Mdl-11,939 PDSP1_001574 AC1L2GSP BDBM50004327 DTXSID4042624 L002081 phenyl-[1-(2-phenylethyl)piperidin-4-yl]methanol ( inverted exclamation markA)-1-phenethyl-a-phenyl-4-piperidinemethanol alpha-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol Glemanserin (USAN/INN) MDL 11,939phenyl[1-(2-phenylethyl)piperidin-4-yl]methanol SR-01000597432 (1-phenethylpiperidin-4-yl)(phenyl)methanol 4-Piperidinemethanol,a-phenyl-1-(2-phenylethyl)- AN-24938 D04320 HMS3266L14 MDL-11939 PDSP2_001558 107703-78-6 AC1Q771C BRD-A62057054-001-01-5 FT-0703731 LS-172057 [ Show all ]
Inchi Key	AXNGJCOYCMDPQG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H25NO/c22-20(18-9-5-2-6-10-18)19-12-15-21(16-13-19)14-11-17-7-3-1-4-8-17/h1-10,19-20,22H,11-16H2
PubChem CID	71781
ChEMBL	CHEMBL18972
IUPHAR	186
BindingDB	50004327
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4700.0 nM	PMID8632342	BindingDB

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