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Name | Neuropeptide Y receptor type 2 |
---|---|
Species | Homo sapiens (Human) |
Gene | NPY2R |
Synonym | NPY2-R NPY-Y2 receptor neuropeptide Y receptor type 2 Y2 receptor |
Disease | Diabetes Metabolic disorders Obesity |
Length | 381 |
Amino acid sequence | MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV |
UniProt | P49146 |
Protein Data Bank | N/A |
GPCR-HGmod model | P49146 |
3D structure model | This predicted structure model is from GPCR-EXP P49146. |
BioLiP | N/A |
Therapeutic Target Database | T10670 |
ChEMBL | CHEMBL4018 |
IUPHAR | 306 |
DrugBank | BE0002419 |
Name | CHEMBL1288285 |
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Molecular formula | C29H35ClF3N3O |
IUPAC name | N-[3-chloro-4-[2-(cyclopropylmethyl)-2,8-diazaspiro[4.5]decan-8-yl]phenyl]-2-methyl-2-[3-(trifluoromethyl)phenyl]propanamide |
Molecular weight | 534.064 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 1 |
XlogP | 6.8 |
Synonyms | BDBM50417494 |
Inchi Key | ACGCDAQKSJBTTB-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C29H35ClF3N3O/c1-27(2,21-4-3-5-22(16-21)29(31,32)33)26(37)34-23-8-9-25(24(30)17-23)36-14-11-28(12-15-36)10-13-35(19-28)18-20-6-7-20/h3-5,8-9,16-17,20H,6-7,10-15,18-19H2,1-2H3,(H,34,37) |
PubChem CID | 50925492 |
ChEMBL | CHEMBL1288285 |
IUPHAR | N/A |
BindingDB | 50417494 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 1.995 nM | PMID21074426 | ChEMBL |
Ki | 2.0 nM | PMID21074426 | BindingDB |
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