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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesRattus norvegicus (Rat)
GeneGhsr
SynonymGH-releasing peptide receptor
Ghrelin receptor
ghrelin receptor 1a
GHRP
GHS-R
[ Show all ]
DiseaseN/A for non-human GPCRs
Length364
Amino acid sequenceMWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
UniProtO08725
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3278
IUPHAR246
DrugBankN/A

Ligand

NameCHEMBL1079622
Molecular formulaC26H23ClN4O2
IUPAC name[(2S)-4-[5-(2-chlorophenyl)pyridine-2-carbonyl]-2-methylpiperazin-1-yl]-(1H-indol-6-yl)methanone
Molecular weight458.946
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP4.4
Synonyms(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(5-(2-chlorophenyl)pyridin-2-yl)methanone
BDBM50312790
Inchi KeyAURAUMNYCSFCEU-KRWDZBQOSA-N
Inchi IDInChI=1S/C26H23ClN4O2/c1-17-16-30(12-13-31(17)25(32)19-7-6-18-10-11-28-24(18)14-19)26(33)23-9-8-20(15-29-23)21-4-2-3-5-22(21)27/h2-11,14-15,17,28H,12-13,16H2,1H3/t17-/m0/s1
PubChem CID46880770
ChEMBLCHEMBL1079622
IUPHARN/A
BindingDB50312790
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity18.0 %PMID20137933ChEMBL

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