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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prokineticin receptor 2
Species	Homo sapiens (Human)
Gene	PROKR2
Synonym	PKR2 PK-R2 I5E GPRg2 GPR73b GPR73a G-protein coupled receptor I5E G-protein coupled receptor 73-like 1 VEGFR-2 [ Show all ]
Disease	N/A
Length	384
Amino acid sequence	MAAQNGNTSFTPNFNPPQDHASSLSFNFSYGDYDLPMDEDEDMTKTRTFFAAKIVIGIALAGIMLVCGIGNFVFIAALTRYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFATETVLFIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGVEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTMKYFKKMMLLHWRPSQRGSKSSADLDLRTNGVPTTEEVDCIRLK
UniProt	Q8NFJ6
Protein Data Bank	N/A
GPCR-HGmod model	Q8NFJ6
3D structure model	This predicted structure model is from GPCR-EXP Q8NFJ6.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5548
IUPHAR	336
DrugBank	N/A

Ligand

Name	CHEMBL459142
Molecular formula	C25H31N7O3
IUPAC name	6-[2-(4,5-dihydro-1H-imidazol-2-ylamino)ethylamino]-3-[(4-ethylphenyl)methyl]-1-[(4-methoxyphenyl)methyl]-1,3,5-triazine-2,4-dione
Molecular weight	477.569
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	1.9
Synonyms	BDBM26337 6-{[2-(4,5-dihydro-1H-imidazol-2-ylamino)ethyl]amino}-3-[(4-ethylphenyl)methyl]-1-[(4-methoxyphenyl)methyl]-1,2,3,4-tetrahydro-1,3,5-triazine-2,4-dione
Inchi Key	IQQIHJNOLKQKPV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H31N7O3/c1-3-18-4-6-19(7-5-18)17-32-24(33)30-23(29-15-14-28-22-26-12-13-27-22)31(25(32)34)16-20-8-10-21(35-2)11-9-20/h4-11H,3,12-17H2,1-2H3,(H2,26,27,28)(H,29,30,33)
PubChem CID	25138122
ChEMBL	CHEMBL459142
IUPHAR	N/A
BindingDB	26337
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	92.0 %	PMID19006379	ChEMBL
Ki	71162.0 nM	PMID19006379	BindingDB,ChEMBL

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