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GLASS

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GPCR

Name	Galanin receptor type 2
Species	Homo sapiens (Human)
Gene	GALR2
Synonym	GAL2 receptor GAL2-R GALNR2 GALR-2
Disease	N/A
Length	387
Amino acid sequence	MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
UniProt	O43603
Protein Data Bank	N/A
GPCR-HGmod model	O43603
3D structure model	This predicted structure model is from GPCR-EXP O43603.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3176
IUPHAR	244
DrugBank	N/A

Ligand

Name	MLS000584180
Molecular formula	C18H15ClN2O2
IUPAC name	2-chloro-3-[4-(dimethylamino)anilino]naphthalene-1,4-dione
Molecular weight	326.78
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.3
Synonyms	2-chloro-3-{[4-(dimethylamino)phenyl]amino}naphthoquinone CHEMBL1451772 NCIOpen2_009955 1,4-Naphthalenedione,2-chloro-3-[[4-(dimethylamino)phenyl]amino]- AC1L63EB DTXSID90293767 SCHEMBL6501763 2-chloro-3-[4-(dimethylamino)anilino]naphthalene-1,4-dione BDBM34778 cid_260557 NSC-92081 2-chloranyl-3-[[4-(dimethylamino)phenyl]amino]naphthalene-1,4-dione AC1Q6B4H HMS2620L09 SMR000203343 2-chloro-3-{[4-(dimethylamino)phenyl]amino}-1,4-naphthoquinone MolPort-003-711-560 42262-96-4 CTK4I5957 NSC92081 2-chloro-3-[4-(dimethylamino)anilino]-1,4-naphthoquinone AKOS001569126 MCULE-5140727957 ZINC175659 [ Show all ]
Inchi Key	IFCBGAQTKDYXAL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H15ClN2O2/c1-21(2)12-9-7-11(8-10-12)20-16-15(19)17(22)13-5-3-4-6-14(13)18(16)23/h3-10,20H,1-2H3
PubChem CID	260557
ChEMBL	CHEMBL1451772
IUPHAR	N/A
BindingDB	34778
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<14000.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL
IC50	8838.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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