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GLASS

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GPCR

Name	Galanin receptor type 2
Species	Homo sapiens (Human)
Gene	GALR2
Synonym	GAL2 receptor GAL2-R GALNR2 GALR-2
Disease	N/A
Length	387
Amino acid sequence	MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
UniProt	O43603
Protein Data Bank	N/A
GPCR-HGmod model	O43603
3D structure model	This predicted structure model is from GPCR-EXP O43603.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3176
IUPHAR	244
DrugBank	N/A

Ligand

Name	MLS000573994
Molecular formula	C21H16ClN3O3S
IUPAC name	N-[4-[[(E)-3-(4-chlorophenyl)prop-2-enoyl]carbamothioylamino]phenyl]furan-2-carboxamide
Molecular weight	425.887
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	4.8
Synonyms	BDBM42053 N-[4-[[(E)-3-(4-chlorophenyl)acryloyl]thiocarbamoylamino]phenyl]-2-furamide cid_1345012 N-{4-[({[3-(4-chlorophenyl)acryloyl]amino}carbonothioyl)amino]phenyl}-2-furamide MolPort-002-210-685 ZINC1181280 AC1LQ8SX N-[4-[[(E)-3-(4-chlorophenyl)prop-2-enoyl]carbamothioylamino]phenyl]furan-2-carboxamide HMS2557B03 SMR000195581 N-[4-({[(2E)-3-(4-chlorophenyl)prop-2-enoyl]carbamothioyl}amino)phenyl]furan-2-carboxamide AKOS003247758 CHEMBL1432794 N-[4-[[[[(E)-3-(4-chlorophenyl)-1-oxoprop-2-enyl]amino]-sulfanylidenemethyl]amino]phenyl]-2-furancarboxamide STK129504 [ Show all ]
Inchi Key	AQWYIXYGJTWAGV-LFYBBSHMSA-N
Inchi ID	InChI=1S/C21H16ClN3O3S/c22-15-6-3-14(4-7-15)5-12-19(26)25-21(29)24-17-10-8-16(9-11-17)23-20(27)18-2-1-13-28-18/h1-13H,(H,23,27)(H2,24,25,26,29)/b12-5+
PubChem CID	1345012
ChEMBL	CHEMBL1432794
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<14000.0 nM	PubChem BioAssay data set	ChEMBL
IC50	6765.0 nM	PubChem BioAssay data set	ChEMBL

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