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GPCR

NameNeuropeptide Y receptor type 4
SpeciesHomo sapiens (Human)
GeneNPY4R
SynonymNPY4-R
neuropeptide Y receptor type 4
pancreatic polypeptide receptor 1
PP1
Y4 receptor
DiseaseObesity
Diabetes
Schizophrenia
Length375
Amino acid sequenceMNTSHLLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNLCLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFIQCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLPFLANSILENVFHKNHSKALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRRLQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAVLWLPLHVFNSLEDWHHEAIPICHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEESEHLPLSTVHTEVSKGSLRLSGRSNPI
UniProtP50391
Protein Data BankN/A
GPCR-HGmod modelP50391
3D structure modelThis predicted structure model is from GPCR-EXP P50391.
BioLiPN/A
Therapeutic Target DatabaseT27944
ChEMBLCHEMBL4877
IUPHAR307
DrugBankBE0002418

Ligand

NameCHEMBL2440933
Molecular formulaC36H49N9O6
IUPAC name(2S)-5-[[amino-[2-[2-(2-aminoethoxy)ethoxy]ethylcarbamoylamino]methylidene]amino]-N-[[4-[(carbamoylamino)methyl]phenyl]methyl]-2-[(2,2-diphenylacetyl)amino]pentanamide
Molecular weight703.845
Hydrogen bond acceptor8
Hydrogen bond donor8
XlogP0.7
SynonymsBDBM50442583
CHEMBL3040765
Inchi KeyHLEBWBDNQCTVJJ-PMERELPUSA-N
Inchi IDInChI=1S/C36H49N9O6/c37-17-20-50-22-23-51-21-19-41-36(49)45-34(38)40-18-7-12-30(32(46)42-24-26-13-15-27(16-14-26)25-43-35(39)48)44-33(47)31(28-8-3-1-4-9-28)29-10-5-2-6-11-29/h1-6,8-11,13-16,30-31H,7,12,17-25,37H2,(H,42,46)(H,44,47)(H3,39,43,48)(H4,38,40,41,45,49)/t30-/m0/s1
PubChem CID72206048
ChEMBLN/A
IUPHARN/A
BindingDB50442583
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki<5000.0 nMPMID24074877BindingDB

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