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BioLiP
Download all results in tab-seperated text for 832530 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
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  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
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    # PDB
    (Resolution Å)
    Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    41801 1q5p:A (1.6) BS02 CA 3.4.21.62 GO:0004252 ... P29600 12962477
    41802 1q5w:A (-1.00) BS01 ZN ? N/A Q9ES54 15029239
    41803 1q5y:A (1.4) BS01 NI ? N/A P0A6Z6 12970756
    41804 1q5y:B (1.4) BS01 NI ? N/A P0A6Z6 12970756
    41805 1q5y:C (1.4) BS01 NI ? N/A P0A6Z6 12970756
    41806 1q5y:D (1.4) BS01 NI ? N/A P0A6Z6 12970756
    41807 1q61:A (2.1) BS01 peptide 2.7.11.11 GO:0001669 ... P00517 12798691
    41808 1q61:A (2.1) BS02 MG8 2.7.11.11 GO:0001669 ... P00517 12798691
    41809 1q62:A (2.3) BS01 peptide 2.7.11.11 GO:0001669 ... P00517 12798691
    41810 1q63:A (1.85) BS01 ZN 2.4.2.29 GO:0002099 ... P28720 15050823
    41811 1q63:A (1.85) BS02 AIQ 2.4.2.29 GO:0002099 ... P28720 15050823 MOAD: Ki=1.4uM
    PDBbind: -logKd/Ki=5.85, Ki=1.4uM
    41812 1q65:A (2.1) BS01 ZN 2.4.2.29 GO:0002099 ... P28720 15050823
    41813 1q65:A (2.1) BS02 BHB 2.4.2.29 GO:0002099 ... P28720 15050823 MOAD: Ki=3.5uM
    PDBbind: -logKd/Ki=5.46, Ki=3.5uM
    41814 1q66:A (1.75) BS01 ZN 2.4.2.29 GO:0002099 ... P28720 15050823
    41815 1q66:A (1.75) BS02 KMB 2.4.2.29 GO:0002099 ... P28720 15050823 MOAD: Ki=1.7uM
    PDBbind: -logKd/Ki=5.77, Ki=1.7uM
    41816 1q68:A (-1.00) BS01 peptide ? N/A P01730 14500983
    41817 1q6c:A (1.86) BS01 GLC 3.2.1.2 GO:0000272 ... P10538 14638688
    41818 1q6c:A (1.86) BS02 GLC 3.2.1.2 GO:0000272 ... P10538 14638688
    41819 1q6c:A (1.86) BS03 GLC 3.2.1.2 GO:0000272 ... P10538 14638688
    41820 1q6c:A (1.86) BS04 GLC 3.2.1.2 GO:0000272 ... P10538 14638688
    41821 1q6d:A (2.0) BS01 GLC 3.2.1.2 GO:0000272 ... P10538 14638688
    41822 1q6d:A (2.0) BS02 GLC 3.2.1.2 GO:0000272 ... P10538 14638688
    41823 1q6d:A (2.0) BS03 BGC 3.2.1.2 GO:0000272 ... P10538 14638688
    41824 1q6d:A (2.0) BS04 GLC 3.2.1.2 GO:0000272 ... P10538 14638688
    41825 1q6e:A (1.95) BS01 GLC 3.2.1.2 GO:0000272 ... P10538 14638688
    41826 1q6e:A (1.95) BS02 GLC 3.2.1.2 GO:0000272 ... P10538 14638688
    41827 1q6e:A (1.95) BS03 GLC 3.2.1.2 GO:0000272 ... P10538 14638688
    41828 1q6f:A (2.1) BS01 BGC 3.2.1.2 GO:0000272 ... P10538 14638688
    41829 1q6f:A (2.1) BS02 BGC 3.2.1.2 GO:0000272 ... P10538 14638688
    41830 1q6f:A (2.1) BS03 BGC 3.2.1.2 GO:0000272 ... P10538 14638688
    41831 1q6f:A (2.1) BS04 GLC 3.2.1.2 GO:0000272 ... P10538 14638688
    41832 1q6g:A (2.0) BS01 GLC 3.2.1.2 GO:0000272 ... P10538 14638688
    41833 1q6g:A (2.0) BS02 GLC 3.2.1.2 GO:0000272 ... P10538 14638688
    41834 1q6g:A (2.0) BS03 GLC 3.2.1.2 GO:0000272 ... P10538 14638688
    41835 1q6i:A (2.25) BS01 FK5 5.2.1.8 GO:0003755 ... P45523 14672666
    41836 1q6i:B (2.25) BS01 FK5 5.2.1.8 GO:0003755 ... P45523 14672666
    41837 1q6j:A (2.2) BS01 335 3.1.3.48 GO:0004725 ... P18031 14516196 MOAD: ic50=0.016uM
    PDBbind: -logKd/Ki=7.80, IC50=0.016uM
    BindingDB: IC50=16nM
    41838 1q6k:A (2.1) BS01 TCO 3.4.22.38 GO:0006508 ... P43235 14684342 MOAD: ic50=26nM
    PDBbind: -logKd/Ki=7.59, IC50=26nM
    BindingDB: IC50=26nM
    41839 1q6l:A (1.8) BS01 MG 4.1.1.85 GO:0000287 ... P39304 14567674
    41840 1q6l:A (1.8) BS02 TX4 4.1.1.85 GO:0000287 ... P39304 14567674
    41841 1q6l:B (1.8) BS01 MG 4.1.1.85 GO:0000287 ... P39304 14567674
    41842 1q6l:B (1.8) BS02 TX4 4.1.1.85 GO:0000287 ... P39304 14567674
    41843 1q6m:A (2.2) BS01 P27 3.1.3.48 GO:0004725 ... P18031 14516196 MOAD: ic50=0.013uM
    PDBbind: -logKd/Ki=7.89, IC50=0.013uM
    BindingDB: IC50=120nM
    41844 1q6n:A (2.1) BS01 P90 3.1.3.48 GO:0004725 ... P18031 14516196 MOAD: ic50=0.023uM
    PDBbind: -logKd/Ki=7.64, IC50=0.023uM
    41845 1q6n:A (2.1) BS02 P90 3.1.3.48 GO:0004725 ... P18031 14516196 MOAD: ic50=0.023uM
    PDBbind: -logKd/Ki=7.64, IC50=0.023uM
    41846 1q6n:B (2.1) BS01 P90 3.1.3.48 GO:0004725 ... P18031 14516196 MOAD: ic50=0.023uM
    41847 1q6n:B (2.1) BS02 P90 3.1.3.48 GO:0004725 ... P18031 14516196 MOAD: ic50=0.023uM
    41848 1q6o:A (1.202) BS01 MG 4.1.1.85 GO:0000287 ... P39304 14567674
    41849 1q6o:A (1.202) BS02 LG6 4.1.1.85 GO:0000287 ... P39304 14567674
    41850 1q6o:B (1.202) BS01 MG 4.1.1.85 GO:0000287 ... P39304 14567674
    41851 1q6o:B (1.202) BS02 LG6 4.1.1.85 GO:0000287 ... P39304 14567674
    41852 1q6p:A (2.3) BS01 213 3.1.3.48 GO:0004725 ... P18031 14516196 MOAD: ic50=3nM
    PDBbind: -logKd/Ki=8.52, IC50=3nM
    BindingDB: IC50=3nM
    41853 1q6p:A (2.3) BS02 213 3.1.3.48 GO:0004725 ... P18031 14516196 MOAD: ic50=3nM
    PDBbind: -logKd/Ki=8.52, IC50=3nM
    BindingDB: IC50=3nM
    41854 1q6p:B (2.3) BS01 213 3.1.3.48 GO:0004725 ... P18031 14516196 MOAD: ic50=3nM
    BindingDB: IC50=3nM
    41855 1q6p:B (2.3) BS02 213 3.1.3.48 GO:0004725 ... P18031 14516196 MOAD: ic50=3nM
    BindingDB: IC50=3nM
    41856 1q6q:A (1.695) BS01 MG 4.1.1.85 GO:0000287 ... P39304 14567674
    41857 1q6q:A (1.695) BS02 LXP 4.1.1.85 GO:0000287 ... P39304 14567674
    41858 1q6q:B (1.695) BS01 MG 4.1.1.85 GO:0000287 ... P39304 14567674
    41859 1q6q:B (1.695) BS02 LXP 4.1.1.85 GO:0000287 ... P39304 14567674
    41860 1q6r:A (1.76) BS01 MG 4.1.1.85 GO:0000287 ... P39304 14567674
    41861 1q6r:A (1.76) BS02 LX1 4.1.1.85 GO:0000287 ... P39304 14567674
    41862 1q6r:B (1.76) BS01 MG 4.1.1.85 GO:0000287 ... P39304 14567674
    41863 1q6r:B (1.76) BS02 LX1 4.1.1.85 GO:0000287 ... P39304 14567674
    41864 1q6s:A (2.2) BS01 214 3.1.3.48 GO:0004725 ... P18031 14516196 MOAD: ic50=12nM
    PDBbind: -logKd/Ki=7.92, IC50=12nM
    BindingDB: IC50=220nM
    41865 1q6s:A (2.2) BS02 214 3.1.3.48 GO:0004725 ... P18031 14516196 MOAD: ic50=12nM
    PDBbind: -logKd/Ki=7.92, IC50=12nM
    BindingDB: IC50=220nM
    41866 1q6s:B (2.2) BS01 214 3.1.3.48 GO:0004725 ... P18031 14516196 MOAD: ic50=12nM
    BindingDB: IC50=220nM
    41867 1q6s:B (2.2) BS02 214 3.1.3.48 GO:0004725 ... P18031 14516196 MOAD: ic50=12nM
    BindingDB: IC50=220nM
    41868 1q6t:A (2.3) BS01 600 3.1.3.48 GO:0004725 ... P18031 14516196 MOAD: ic50=5nM
    PDBbind: -logKd/Ki=8.30, IC50=5nM
    BindingDB: IC50=5340nM
    41869 1q6t:A (2.3) BS02 600 3.1.3.48 GO:0004725 ... P18031 14516196 MOAD: ic50=5nM
    PDBbind: -logKd/Ki=8.30, IC50=5nM
    BindingDB: IC50=5340nM
    41870 1q6t:B (2.3) BS01 600 3.1.3.48 GO:0004725 ... P18031 14516196 MOAD: ic50=5nM
    BindingDB: IC50=5340nM
    41871 1q6t:B (2.3) BS02 600 3.1.3.48 GO:0004725 ... P18031 14516196 MOAD: ic50=5nM
    BindingDB: IC50=5340nM
    41872 1q6y:A (1.99) BS01 COA 2.8.3.16 GO:0003824 ... P69902 14993676
    41873 1q6z:A (1.0) BS01 MG 4.1.1.7 GO:0000287 ... P20906 N/A
    41874 1q6z:A (1.0) BS02 CA 4.1.1.7 GO:0000287 ... P20906 N/A
    41875 1q6z:A (1.0) BS03 TZD 4.1.1.7 GO:0000287 ... P20906 N/A
    41876 1q74:A (1.7) BS01 ZN 3.5.1.103 GO:0005886 ... P9WJN3 12958317
    41877 1q74:B (1.7) BS01 ZN 3.5.1.103 GO:0005886 ... P9WJN3 12958317
    41878 1q74:C (1.7) BS01 ZN 3.5.1.103 GO:0005886 ... P9WJN3 12958317
    41879 1q74:D (1.7) BS01 ZN 3.5.1.103 GO:0005886 ... P9WJN3 12958317
    41880 1q78:A (2.8) BS01 3AT 2.7.7.19 GO:0003723 ... P25500 15328606
    41881 1q79:A (2.15) BS01 MN 2.7.7.19 GO:0003723 ... P25500 15328606
    41882 1q79:A (2.15) BS02 MN 2.7.7.19 GO:0003723 ... P25500 15328606
    41883 1q79:A (2.15) BS03 3AT 2.7.7.19 GO:0003723 ... P25500 15328606
    41884 1q7a:A (1.6) BS01 SO4 3.1.1.4 GO:0004623 ... P59071 15544328
    41885 1q7a:A (1.6) BS02 OPB 3.1.1.4 GO:0004623 ... P59071 15544328 MOAD: Kd=0.000000064M
    PDBbind: -logKd/Ki=7.19, Kd=64nM
    41886 1q7b:A (2.05) BS01 CA 1.1.1.100 GO:0004316 ... P0AEK2 15016358
    41887 1q7b:A (2.05) BS02 NAP 1.1.1.100 GO:0004316 ... P0AEK2 15016358 MOAD: Kd=3.5uM
    41888 1q7b:B (2.05) BS01 CA 1.1.1.100 GO:0004316 ... P0AEK2 15016358
    41889 1q7b:B (2.05) BS02 CA 1.1.1.100 GO:0004316 ... P0AEK2 15016358
    41890 1q7b:B (2.05) BS03 NAP 1.1.1.100 GO:0004316 ... P0AEK2 15016358 MOAD: Kd=3.5uM
    41891 1q7b:C (2.05) BS01 CA 1.1.1.100 GO:0004316 ... P0AEK2 15016358
    41892 1q7b:C (2.05) BS02 NAP 1.1.1.100 GO:0004316 ... P0AEK2 15016358 MOAD: Kd=3.5uM
    41893 1q7b:D (2.05) BS01 CA 1.1.1.100 GO:0004316 ... P0AEK2 15016358
    41894 1q7b:D (2.05) BS02 NAP 1.1.1.100 GO:0004316 ... P0AEK2 15016358 MOAD: Kd=3.5uM
    41895 1q7c:A (2.5) BS01 NDP 1.1.1.100 GO:0004316 ... P0AEK2 15016358
    41896 1q7c:B (2.5) BS01 NDP 1.1.1.100 GO:0004316 ... P0AEK2 15016358
    41897 1q7e:A (1.6) BS01 MET 2.8.3.16 GO:0003824 ... P69902 14993676
    41898 1q7e:A (1.6) BS02 MET 2.8.3.16 GO:0003824 ... P69902 14993676
    41899 1q7g:A (2.6) BS01 NHO 1.1.1.3 GO:0004412 ... P31116 14583265
    41900 1q7l:A (1.4) BS01 ZN 3.5.1.14 GO:0004046 ... Q03154 12933810
    41901 1q7l:A (1.4) BS02 ZN 3.5.1.14 GO:0004046 ... Q03154 12933810
    41902 1q7l:A (1.4) BS03 GLY 3.5.1.14 GO:0004046 ... Q03154 12933810
    41903 1q7l:C (1.4) BS01 ZN 3.5.1.14 GO:0004046 ... Q03154 12933810
    41904 1q7l:C (1.4) BS02 ZN 3.5.1.14 GO:0004046 ... Q03154 12933810
    41905 1q7l:C (1.4) BS03 GLY 3.5.1.14 GO:0004046 ... Q03154 12933810
    41906 1q7t:A (1.9) BS01 BOG 3.5.1.103 GO:0005886 ... P9WJN3 14698305
    41907 1q7t:A (1.9) BS02 BOG 3.5.1.103 GO:0005886 ... P9WJN3 14698305
    41908 1q7t:B (1.9) BS01 BOG 3.5.1.103 GO:0005886 ... P9WJN3 14698305
    41909 1q7t:B (1.9) BS02 BOG 3.5.1.103 GO:0005886 ... P9WJN3 14698305
    41910 1q7y:1 (3.2) BS01 rna ? GO:0003735 ... P60619 12185246
    41911 1q7y:2 (3.2) BS01 rna ? GO:0003723 ... P32410 12185246
    41912 1q7y:3 (3.2) BS01 rna ? GO:0003735 ... P22452 12185246
    41913 1q7y:4 (3.2) BS01 rna ? GO:0000049 ... P32411 12185246
    41914 1q7y:4 (3.2) BS02 MG ? GO:0000049 ... P32411 12185246
    41915 1q7y:C (3.2) BS01 rna ? GO:0002181 ... P20276 12185246
    41916 1q7y:C (3.2) BS02 MG ? GO:0002181 ... P20276 12185246
    41917 1q7y:D (3.2) BS01 rna ? GO:0003723 ... P20279 12185246
    41918 1q7y:E (3.2) BS01 rna ? GO:0003723 ... P12735 12185246
    41919 1q7y:F (3.2) BS01 rna ? GO:0000049 ... P14124 12185246
    41920 1q7y:F (3.2) BS02 rna ? GO:0000049 ... P14124 12185246
    41921 1q7y:G (3.2) BS01 rna ? GO:0002181 ... P14135 12185246
    41922 1q7y:H (3.2) BS01 rna ? GO:0001682 ... P12743 12185246
    41923 1q7y:J (3.2) BS01 rna ? GO:0000027 ... P60617 12185246
    41924 1q7y:K (3.2) BS01 rna ? GO:0003729 ... P29198 12185246
    41925 1q7y:L (3.2) BS01 rna ? GO:0003735 ... P22450 12185246
    41926 1q7y:M (3.2) BS01 rna ? GO:0003735 ... P12737 12185246
    41927 1q7y:N (3.2) BS01 rna ? GO:0002181 ... P60618 12185246
    41928 1q7y:O (3.2) BS01 rna ? GO:0000027 ... P14123 12185246
    41929 1q7y:O (3.2) BS02 rna ? GO:0000027 ... P14123 12185246
    41930 1q7y:P (3.2) BS01 rna ? GO:0003723 ... P12733 12185246
    41931 1q7y:Q (3.2) BS01 rna ? GO:0003723 ... P14119 12185246
    41932 1q7y:R (3.2) BS01 rna ? GO:0003735 ... P12734 12185246
    41933 1q7y:R (3.2) BS02 rna ? GO:0003735 ... P12734 12185246
    41934 1q7y:S (3.2) BS01 rna ? GO:0002181 ... P10970 12185246
    41935 1q7y:T (3.2) BS01 rna ? GO:0000027 ... P12732 12185246
    41936 1q7y:U (3.2) BS01 rna ? GO:0002181 ... P10972 12185246
    41937 1q7y:U (3.2) BS02 MG ? GO:0002181 ... P10972 12185246
    41938 1q7y:V (3.2) BS01 rna ? GO:0003735 ... P14116 12185246
    41939 1q7y:W (3.2) BS01 rna ? GO:0003735 ... P10971 12185246
    41940 1q7y:X (3.2) BS01 rna ? GO:0000463 ... P14121 12185246
    41941 1q7y:X (3.2) BS02 rna ? GO:0000463 ... P14121 12185246
    41942 1q7y:Y (3.2) BS01 rna ? GO:0002181 ... P18138 12185246
    41943 1q7y:Z (3.2) BS01 rna ? GO:0000166 ... P12736 12185246
    41944 1q7y:Z (3.2) BS02 MG ? GO:0000166 ... P12736 12185246
    41945 1q81:1 (2.95) BS01 rna ? GO:0003735 ... P60619 12185246
    41946 1q81:2 (2.95) BS01 rna ? GO:0003723 ... P32410 12185246
    41947 1q81:3 (2.95) BS01 rna ? GO:0003735 ... P22452 12185246
    41948 1q81:4 (2.95) BS01 rna ? GO:0000049 ... P32411 12185246
    41949 1q81:4 (2.95) BS02 MG ? GO:0000049 ... P32411 12185246
    41950 1q81:C (2.95) BS01 rna ? GO:0002181 ... P20276 12185246
    41951 1q81:C (2.95) BS02 MG ? GO:0002181 ... P20276 12185246
    41952 1q81:D (2.95) BS01 rna ? GO:0003723 ... P20279 12185246
    41953 1q81:E (2.95) BS01 rna ? GO:0003723 ... P12735 12185246
    41954 1q81:F (2.95) BS01 rna ? GO:0000049 ... P14124 12185246
    41955 1q81:F (2.95) BS02 rna ? GO:0000049 ... P14124 12185246
    41956 1q81:G (2.95) BS01 rna ? GO:0002181 ... P14135 12185246
    41957 1q81:H (2.95) BS01 rna ? GO:0001682 ... P12743 12185246
    41958 1q81:J (2.95) BS01 rna ? GO:0000027 ... P60617 12185246
    41959 1q81:K (2.95) BS01 rna ? GO:0003729 ... P29198 12185246
    41960 1q81:L (2.95) BS01 rna ? GO:0003735 ... P22450 12185246
    41961 1q81:M (2.95) BS01 rna ? GO:0003735 ... P12737 12185246
    41962 1q81:N (2.95) BS01 rna ? GO:0002181 ... P60618 12185246
    41963 1q81:O (2.95) BS01 rna ? GO:0000027 ... P14123 12185246
    41964 1q81:O (2.95) BS02 rna ? GO:0000027 ... P14123 12185246
    41965 1q81:P (2.95) BS01 rna ? GO:0003723 ... P12733 12185246
    41966 1q81:Q (2.95) BS01 rna ? GO:0003723 ... P14119 12185246
    41967 1q81:R (2.95) BS01 rna ? GO:0003735 ... P12734 12185246
    41968 1q81:R (2.95) BS02 rna ? GO:0003735 ... P12734 12185246
    41969 1q81:S (2.95) BS01 rna ? GO:0002181 ... P10970 12185246
    41970 1q81:T (2.95) BS01 rna ? GO:0000027 ... P12732 12185246
    41971 1q81:U (2.95) BS01 rna ? GO:0002181 ... P10972 12185246
    41972 1q81:U (2.95) BS02 MG ? GO:0002181 ... P10972 12185246
    41973 1q81:V (2.95) BS01 rna ? GO:0003735 ... P14116 12185246
    41974 1q81:W (2.95) BS01 rna ? GO:0003735 ... P10971 12185246
    41975 1q81:X (2.95) BS01 rna ? GO:0000463 ... P14121 12185246
    41976 1q81:X (2.95) BS02 rna ? GO:0000463 ... P14121 12185246
    41977 1q81:Y (2.95) BS01 rna ? GO:0002181 ... P18138 12185246
    41978 1q81:Z (2.95) BS01 rna ? GO:0000166 ... P12736 12185246
    41979 1q81:Z (2.95) BS02 MG ? GO:0000166 ... P12736 12185246
    41980 1q82:1 (2.98) BS01 rna ? GO:0003735 ... P60619 12185246
    41981 1q82:2 (2.98) BS01 rna ? GO:0003723 ... P32410 12185246
    41982 1q82:3 (2.98) BS01 rna ? GO:0003735 ... P22452 12185246
    41983 1q82:4 (2.98) BS01 rna ? GO:0000049 ... P32411 12185246
    41984 1q82:4 (2.98) BS02 MG ? GO:0000049 ... P32411 12185246
    41985 1q82:C (2.98) BS01 rna ? GO:0002181 ... P20276 12185246
    41986 1q82:C (2.98) BS02 MG ? GO:0002181 ... P20276 12185246
    41987 1q82:D (2.98) BS01 rna ? GO:0003723 ... P20279 12185246
    41988 1q82:E (2.98) BS01 rna ? GO:0003723 ... P12735 12185246
    41989 1q82:F (2.98) BS01 rna ? GO:0000049 ... P14124 12185246
    41990 1q82:F (2.98) BS02 rna ? GO:0000049 ... P14124 12185246
    41991 1q82:G (2.98) BS01 rna ? GO:0002181 ... P14135 12185246
    41992 1q82:H (2.98) BS01 rna ? GO:0001682 ... P12743 12185246
    41993 1q82:J (2.98) BS01 rna ? GO:0000027 ... P60617 12185246
    41994 1q82:K (2.98) BS01 rna ? GO:0003729 ... P29198 12185246
    41995 1q82:L (2.98) BS01 rna ? GO:0003735 ... P22450 12185246
    41996 1q82:M (2.98) BS01 rna ? GO:0003735 ... P12737 12185246
    41997 1q82:N (2.98) BS01 rna ? GO:0002181 ... P60618 12185246
    41998 1q82:O (2.98) BS01 rna ? GO:0000027 ... P14123 12185246
    41999 1q82:O (2.98) BS02 rna ? GO:0000027 ... P14123 12185246
    42000 1q82:P (2.98) BS01 rna ? GO:0003723 ... P12733 12185246

    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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