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- Fri Nov 15, 2024 2:33 am
- Forum: Main Forum
- Topic: Take into account pLDDT into TM-score
- Replies: 3
- Views: 8514
Re: Take into account pLDDT into TM-score
bitlife Hi, I am currently superimposing protein structures of different species with TM-Align and using a TM-score threshold to filter. However, I have realized that, since I am using AlphaFold structures, the TM-score is heavily influenced by low pLDDT regions that appear as disordered coils. As ...