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I-TASSER results for job id S802580

(Click on S802580_results.tar.bz2 to download the tarball file including all modeling results listed on this page. Click on Annotation of I-TASSER Output to read the instructions for how to interpret the results on this page. Model results are kept on the server for 60 days, there is no way to retrieve the modeling data older than 2 months)

Submitted Sequence in FASTA format

>protein
AFRPCNVNTKIGNAKCCPFVCGKAVTFKDRSTCSTYNLSSSLHHILEEDKRRRQVVDVMS
AIFQGPISLDAPPPPAIADLLQSVRTPRVIKYCQIIMGHPAECQVERDLNIANSIIAIIA
NIISIAGIIFVIYKLFCSLQGPYSGEPKPKTKVPERRVVAQGPEEEFGRSILKNNTCVIT
TGNGKFTGLGIHDRILIIPTHADPGREVQVNGVHTKVLDSYDLYNRDGVKLEITVIQLDR
NEKFRDIRKYIPETEDDYPECNLALSANQDEPTIIKVGDVVSYGNILLSGNQTARMLKYN
YPTKSGYCGGVLYKIGQILGIHVGGNGRDGFSAMLLRSYFTGQIKVNKHATECGLPDIQT
IHTPSKTKLQPSVFYDVFPGSKEPAVLTDNDPRLEVNFKEA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| AFRPCNVNTKIGNAKCCPFVCGKAVTFKDRSTCSTYNLSSSLHHILEEDKRRRQVVDVMSAIFQGPISLDAPPPPAIADLLQSVRTPRVIKYCQIIMGHPAECQVERDLNIANSIIAIIANIISIAGIIFVIYKLFCSLQGPYSGEPKPKTKVPERRVVAQGPEEEFGRSILKNNTCVITTGNGKFTGLGIHDRILIIPTHADPGREVQVNGVHTKVLDSYDLYNRDGVKLEITVIQLDRNEKFRDIRKYIPETEDDYPECNLALSANQDEPTIIKVGDVVSYGNILLSGNQTARMLKYNYPTKSGYCGGVLYKIGQILGIHVGGNGRDGFSAMLLRSYFTGQIKVNKHATECGLPDIQTIHTPSKTKLQPSVFYDVFPGSKEPAVLTDNDPRLEVNFKEA
Prediction	CCCCCCCCCCCCCCCCCCCCCCSSSSSSSCCCCCSSCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCSSSSSCCCCHHHHHHHHHCCSSSSSSCCCSSSSSSSSCCSSSSSCCCCCCCSSSSCCSSSSSSSSSSSSSCCCCCCSSSSSSCCCCCCCCCCHHHCCCCCCCCCCCSSSSSCCCCCCSSSSSSSSSSSCCCCCCCCCCCCSSSSSCCCCCCCCCCSSSSCCCSSSSSSCCCCCCSSSSSSCHHHHHHHHHCSSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	97727899998731479715355689997898817719999999999998776666668987528866677881779999984598379898764003564202231689999999999999999999999986504666787888876777765133323980788998875525799968846999998277999866778886799948898866789999179982048999879988668725644456667887559998078875699953178842111789713437999616779865744875697899997579985487521288776344003213452677887654778706756775105478620787899998878676769
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| AFRPCNVNTKIGNAKCCPFVCGKAVTFKDRSTCSTYNLSSSLHHILEEDKRRRQVVDVMSAIFQGPISLDAPPPPAIADLLQSVRTPRVIKYCQIIMGHPAECQVERDLNIANSIIAIIANIISIAGIIFVIYKLFCSLQGPYSGEPKPKTKVPERRVVAQGPEEEFGRSILKNNTCVITTGNGKFTGLGIHDRILIIPTHADPGREVQVNGVHTKVLDSYDLYNRDGVKLEITVIQLDRNEKFRDIRKYIPETEDDYPECNLALSANQDEPTIIKVGDVVSYGNILLSGNQTARMLKYNYPTKSGYCGGVLYKIGQILGIHVGGNGRDGFSAMLLRSYFTGQIKVNKHATECGLPDIQTIHTPSKTKLQPSVFYDVFPGSKEPAVLTDNDPRLEVNFKEA
Prediction	73421764343303300000023002020343433120230032014225315403420300010223454432610230042064750251054342334513033213101200002002110201010002223643221634336434445240343123441041003300020314413000000211000000003443303034250413312302337424000000102436413301420254364243010002034322010302403424322144330120020203133010000002412000000003222000010034204531433443341524624302003303033010120132632102027604106242678
	Values range from 0 (buried residue) to 9 (highly exposed residue)

Predicted normalized B-factor

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

(I-TASSER modeling starts from the structure templates identified by LOMETS from the PDB library. LOMETS is a meta-server threading approach containing multiple threading programs, where each threading program can generate tens of thousands of template alignments. I-TASSER only uses the templates of the highest significance in the threading alignments, the significance of which are measured by the Z-score, i.e. the difference between the raw and average scores in the unit of standard deviation. The templates in this section are the 10 best templates selected from the LOMETS threading programs. Usually, one template of the highest Z-score is selected from each threading program, where the threading programs are sorted by the average performance in the large-scale benchmark test experiments.)

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Z-score

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   | 

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCSSSSSSSCCCCCSSCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCSSSSSCCCCHHHHHHHHHCCSSSSSSCCCSSSSSSSSCCSSSSSCCCCCCCSSSSCCSSSSSSSSSSSSSCCCCCCSSSSSSCCCCCCCCCCHHHCCCCCCCCCCCSSSSSCCCCCCSSSSSSSSSSSCCCCCCCCCCCCSSSSSCCCCCCCCCCSSSSCCCSSSSSSCCCCCCSSSSSSCHHHHHHHHHCSSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AFRPCNVNTKIGNAKCCPFVCGKAVTFKDRSTCSTYNLSSSLHHILEEDKRRRQVVDVMSAIFQGPISLDAPPPPAIADLLQSVRTPRVIKYCQIIMGHPAECQVERDLNIANSIIAIIANIISIAGIIFVIYKLFCSLQGPYSGEPKPKTKVPERRVVAQGPEEEFGRSILKNNTCVITTGNGKFTGLGIHDRILIIPTHADPGREVQVNGVHTKVLDSYDLYNRDGVKLEITVIQLDRNEKFRDIRKYIPETEDDYPECNLALSANQDEPTIIKVGDVVSYGNILLSGNQTARMLKYNYPTKSGYCGGVLYKIGQILGIHVGGNGRDGFSAMLLRSYFTGQIKVNKHATECGLPDIQTIHTPSKTKLQPSVFYDVFPGSKEPAVLTDNDPRLEVNFKEA

1cqqA

0.82

0.37

0.45

1.32

Download

-----------------------------------------------------------------------------------------------------------------------------------------------------------------GPEEEFGMSLIKHNSCVITTENGKFTGLGVYDRFVVVPTHADPGKEIQVDGITTKVIDSYDLYNKNGIKLEITVLKLDRNEKFRDIRRYIPNNEDDYPNCNLALLANQPEPTIINVGDVVSYGNILLSGNQTARMLKYSYPTKSGYCGGVLYKIGQVLGIHVGGNGRDGFSAMLLRSYFT------------------------------------------------------------

7p4lA

0.05

0.19

0.85

1.15

Download

DSITYNSGTSEFFDGDVADQSTDEIDIYLNQSDELRDIVTLTTYYEDGFDTEQDAIDAIKSDCYDLNQNGNGSGRYSRYYSVTASEPENSRVIALYSNDFENGWRIGNKQSYEDYKTFIGGGDAYDLLIDWANQAVEEASSSTTDLVNAKVKDSSLDT---------------GSFVYDTPELLSYPSFTVYNGYIEVTKPTGDPDIISTEGDEGTVCATVENVGDGEGEFSGRLSSCGEGFSIVDDQNTKNVGAGESVTYSFDVAFSSVSSESKEISGSCTFEVNGVESSDSTSVSVTGIQQSECNPGDQRRENDRWEIYTCQDNGLTYEYDVT--------------------------------------------CAEDEKAVAQGDNQFKEHHHHH

7l8hA

0.48

0.22

0.46

1.79

Download

------------------------------------------------------------------------------------------------------------------------------------------------------------SHMASGPGFDFAQAIMKKNTVIARTEKGEFTMLGVYDRVAVIPTHASVGETIYINDVETKVLDACALRDLTDTNLEITIVKLDRNQKFRDIRHFLPRYEDDYNDAVLSVHTSKFPNMYIPVGQVTNYGFLNLGGTPTHRILMYNFPTRAGQCGGVVTTTGKVIGIHVGGNGAQGFAAMLLHSYFS------------------------------------------------------------

7n88A

0.09

0.24

0.88

1.13

Download

VNRPTAFHREDGTAIPDSKQAEEKLSFKEGDVLFLYGSKGNKLQQLKSEIHKR-----------DSDVEIRTSEKENKKYYTKNGKDEIEQNSGGK---------------------------------RFTHRFGYKRHRTGKAVASDDLGYITFYGNDIGATSYAAKDADDREKHPAEYPKKPLTIYNITKEYLFFHTDADQRLEGGFFGDNGEELAGRFISNDNGVFGVFAGKQKTNASGTNPAMPFGKHTKILSVDFEVSTMPDFGHPDSKEKTIDLKMTVSACCDFLTYVKLGRIKTERKGRDIDLFLKGIRTAWEARIGEPIQW-----DNKADKAAKAEFDSGTLTEQNGVEPAFRIENGVNKDGKSLGITEDIENEVENEADVGEQLEPEVKP

2ijd

0.46

0.28

0.59

4.23

Download

-----------------------------------------------------------------------------------------------------------------------------------------------------------------GPGFDYAVAMAKRNIVTATTSKGEFTMLGVHDNVAILPTHASPGESIVIDGKEVAILAAKALADQAGTNLEITIITLKRNEKFRDIRPHIPTQITETNDGVLIVNTSKYPNMYVPVGAVTEQGYLNLGGRQTARTLMYNFPTRAGQAGGVITCTGKVIGMHVGGNGSHGFAAALKRSYFTGEIQWMRPSK---EVGYPIINAPSKTKLEPSAFHYVFEGVKEPAVLTKNDPRLKTDFEEA

2ijd

0.44

0.28

0.60

3.43

Download

-----------------------------------------------------------------------------------------------------------------------------------------------------------------GPGFDYAVAMAKRNIVTATTSKGEFTMLGVHDNVAILPTHASPGESIVIDGKEVAILAAKALADQAGTNLEITIITLKRNEKFRDIRPHIPTQITETNDGVLIVNTSKYPNMYVPVGAVTEQGYLNLGGRQTARTLMYNFPTRAGQAGGVITCTGKVIGMHVGGNGSHGFAAALKRSYFTQSQGEIQWMRPSKEVGYPIINAPSKTKLEPSAFHYVFEGVKEPAVLTKNDPRLKTDFEEA

1cqqA

0.82

0.37

0.45

1.82

Download

-----------------------------------------------------------------------------------------------------------------------------------------------------------------GPEEEFGMSLIKHNSCVITTENGKFTGLGVYDRFVVVPTHADPGKEIQVDGITTKVIDSYDLYNKNGIKLEITVLKLDRNEKFRDIRRYIPNNEDDYPNCNLALLANQPEPTIINVGDVVSYGNILLSGNQTARMLKYSYPTKSGYCGGVLYKIGQVLGIHVGGNGRDGFSAMLLRSYFT------------------------------------------------------------

2ijd

0.44

0.28

0.60

5.64

Download

-----------------------------------------------------------------------------------------------------------------------------------------------------------------GPGFDYAVAMAKRNIVTATTSKGEFTMLGVHDNVAILPTHASPGESIVIDGKEVAILAAKALADQAGTNLEITIITLKRNEKFRDIRPHIPTQITETNDGVLIVNTSKYPNMYVPVGAVTEQGYLNLGGRQTARTLMYNFPTRAGQAGGVITCTGKVIGMHVGGNGSHGFAAALKRSYFTQSQGEIQWMRPSKEVGYPIINAPSKTKLEPSAFHYVFEGVKEPAVLTKNDPRLKTDFEE-

2ijdA

0.44

0.28

0.60

4.86

Download

-----------------------------------------------------------------------------------------------------------------------------------------------------------------GPGFDYAVAMAKRNIVTATTSKGEFTMLGVHDNVAILPTHASPGESIVIDGKEVAILAAKALADQAGTNLEITIITLKRNEKFRDIRPHIPTQITETNDGVLIVNTSKYPNMYVPVGAVTEQGYLNLGGRQTARTLMYNFPTRAGQAGGVITCTGKVIGMHVGGNGSHGFAAALKRSYFTQSQGEIQWMRPSKEVGYPIINAPSKTKLEPSAFHYVFEGVKEPAVLTKNDPRLKTDFEEA

7wylA

0.45

0.20

0.45

2.12

Download

-----------------------------------------------------------------------------------------------------------------------------------------------------------------GPSLDFALSLLRRNVRQVQTDQGHFTMLGVRDRLAVLPRHSQPGKTIWIEHKLVNVLDAVELVDEQGVNLELTLITLDTNEKFRDITKFIPENISTASDATLVINTEHMPSMFVPVGDVVQYGFLNLSGKPTGRTMMYNFPTKAGQCGGVVTSVGKIIGIHIGGNGRQGFCAGLKRSYF-----------------------------------------------------------AS

(a)	All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)	Rank of templates represents the top ten threading templates used by I-TASSER.
(c)	Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)	Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)	Cov represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)	Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)	Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)	The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
	1: MUSTER 2: PROSPECT2 3: SPARKS-X 4: PROSPECT2 5: HHSEARCH2 6: HHSEARCH I 7: Neff-PPAS 8: HHSEARCH 9: pGenTHREADER 10: PROSPECT2

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of a higher value signifies a model with a higher confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated; this is usually an indication that the models have a good quality because of the converged simulations.)

(By right-click on the images, you can export image file or change the configurations, e.g. modifying the background color or stopping the spin of your models)

Download Model 1 C-score=-1.86 (Read more about C-score) Estimated TM-score = 0.49±0.15 Estimated RMSD = 11.2±4.6Å	Download Model 2 C-score = -2.17	Download Model 3 C-score = -3.72	Download Model 4 C-score = -3.31	Download Model 5 C-score = -2.40

Proteins structurally close to the target in the PDB (as identified by TM-align)

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	Alignment
1	7p4lA	0.755	2.74	0.047	0.820	Download
2	5mf1A	0.501	4.98	0.073	0.676	Download
3	5ow3C	0.490	5.02	0.081	0.651	Download
4	7a4aA	0.457	5.35	0.082	0.626	Download
5	5g47A	0.450	5.38	0.044	0.623	Download
6	7fgfA	0.448	5.12	0.034	0.616	Download
7	7a59A	0.447	5.14	0.034	0.619	Download
8	4ojcA	0.427	5.53	0.074	0.606	Download
9	1rerA	0.426	5.41	0.071	0.594	Download
10	3k71G	0.416	6.66	0.049	0.666	Download

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COFACTOR and COACH

(This section reports biological annotations of the target protein by COFACTOR and COACH based on the I-TASSER structure prediction. While COFACTOR deduces protein functions (ligand-binding sites, EC and GO) using structure comparison and protein-protein networks, COACH is a meta-server approach that combines multiple function annotation results (on ligand-binding sites) from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.30	20	1cqqA	AG7	N/A	183,185,186,201,232,286,287,288,289,291,303,304,305,306,307,308,322,323,324,325,326,331
2	0.10	7	3q3yA	XNV	N/A	201,232,286,288,289,303,305,306,308,322,323,324,325,326,329,331
3	0.03	2	3k71E	k-mer	Rep, Mult	314,331,333,335
4	0.02	1	2ztxA	DTZ	N/A	186,201,308
5	0.02	1	2xyaA	7L4	N/A	303,304,305,308,322,323,324,325,326,327

	Download the residue-specific ligand binding probability, which is estimated by SVM.
	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.119	1rerA	0.426	5.41	0.071	0.594	3.4.21.90	307,320,338
2	0.108	3eqlM	0.369	6.96	0.059	0.609	2.7.7.6	NA
3	0.103	2np0A	0.359	6.67	0.057	0.576	3.4.24.69	NA
4	0.096	1k32A	0.363	7.10	0.029	0.623	3.4.21.-	NA
5	0.092	2vdcF	0.351	7.21	0.059	0.606	1.4.1.13	NA

	Click on the radio buttons to visualize predicted active site residues.
(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Top 10 homologous GO templates in PDB
1	0.17	0.4260	5.41	0.07	0.59	1rerA	GO:0004252 GO:0016021 GO:0019028 GO:0019031 GO:0055036
2	0.11	0.3986	6.04	0.04	0.60	3g7tA	GO:0005198 GO:0016021 GO:0019031
3	0.11	0.3948	6.96	0.02	0.67	3k6sE	GO:0005515 GO:0016021 GO:0008305 GO:0050900 GO:0004872 GO:0005886 GO:0007155 GO:0009887 GO:0007596 GO:0007229 GO:0016020
4	0.10	0.3746	6.55	0.06	0.60	3fcsA	GO:0007229 GO:0005887 GO:0016020 GO:0030168 GO:0002576 GO:0007596 GO:0050840 GO:0007411 GO:0004872 GO:0005925 GO:0016021 GO:0031092 GO:0005886 GO:0007155 GO:0009897 GO:0007160 GO:0042802 GO:0008305
5	0.10	0.3690	6.75	0.04	0.60	1iw7C	GO:0032549 GO:0003677 GO:0003899 GO:0016740 GO:0016779 GO:0006351 GO:0005515
6	0.09	0.2976	7.44	0.04	0.53	3aoiM	GO:0006351 GO:0003899 GO:0016740 GO:0003677 GO:0016779 GO:0005515 GO:0032549
7	0.09	0.3062	7.38	0.04	0.54	2p5oD	GO:0003676 GO:0006139 GO:0016740 GO:0016779 GO:0016787 GO:0003677 GO:0006260 GO:0000166 GO:0004518 GO:0003887 GO:0004527
8	0.09	0.3574	7.38	0.03	0.62	2oyqA	GO:0003677 GO:0003676 GO:0003887 GO:0006260 GO:0016740 GO:0000166 GO:0006139 GO:0004518 GO:0004527 GO:0016779 GO:0016787
9	0.08	0.2748	7.45	0.03	0.48	3g5uA	GO:0005886 GO:0005524 GO:0042623 GO:0008559 GO:0006200 GO:0000166 GO:0015893 GO:0016787 GO:0016020 GO:0046581 GO:0016021 GO:0006810 GO:0016887 GO:0017111 GO:0042626 GO:0055085
10	0.08	0.3673	7.24	0.05	0.63	3iayA	GO:0000166 GO:0003676 GO:0003677 GO:0003887 GO:0006139 GO:0006260

Consensus prediction of GO terms

Molecular Function GO:0017171 GO:0004175

GO-Score 0.33 0.33

Biological Process GO:0042060 GO:0007599 GO:0007166 GO:0022610 GO:0050817

GO-Score 0.41 0.41 0.41 0.41 0.41

Cellular Component GO:0044423 GO:0043235 GO:0005887

GO-Score 0.52 0.41 0.37

(a) Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.

(b) TM-score is a measure of global structural similarity between query and template protein.

(c) RMSD^a is the RMSD between residues that are structurally aligned by TM-align.

(d) IDEN^a is the percentage sequence identity in the structurally aligned region.

(e) Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

(f) The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on S802580_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

Please cite the following articles when you use the I-TASSER server:

Wei Zheng, Chengxin Zhang, Yang Li, Robin Pearce, Eric W. Bell, Yang Zhang. Folding non-homology proteins by coupling deep-learning contact maps with I-TASSER assembly simulations. Cell Reports Methods, 1: 100014 (2021).
Chengxin Zhang, Peter L. Freddolino, and Yang Zhang. COFACTOR: improved protein function prediction by combining structure, sequence and protein-protein interaction information. Nucleic Acids Research, 45: W291-299 (2017).
Jianyi Yang, Yang Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.